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    Scgb3a1 secretoglobin, family 3A, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 68662, updated on 27-Nov-2024

    Summary

    Official Symbol
    Scgb3a1provided by MGI
    Official Full Name
    secretoglobin, family 3A, member 1provided by MGI
    Primary source
    MGI:MGI:1915912
    See related
    Ensembl:ENSMUSG00000064057 AllianceGenome:MGI:1915912
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HIN-1; Pnsp2; UGRP2; LuLeu2; Utgrp2
    Summary
    This gene encodes a small secreted protein that may function in the inhibition of cell growth. Expression of the related gene in humans is downregulated via DNA methylation in breast cancers and other tumor types. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]
    Expression
    Restricted expression toward lung adult (RPKM 699.5) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Scgb3a1 in Genome Data Viewer
    Location:
    11 B1.2; 11 29.75 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (49554422..49555945)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (49663595..49665118)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42075 Neighboring gene predicted gene 12190 Neighboring gene FMS-like tyrosine kinase 4 Neighboring gene STARR-seq mESC enhancer starr_29379 Neighboring gene CCR4-NOT transcription complex, subunit 6 Neighboring gene ribosomal protein L30 pseudogene Neighboring gene predicted gene 12192

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC107611

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of myoblast fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    secretoglobin family 3A member 1
    Names
    cytokine HIN-1
    high in normal 1
    pneumo secretory protein 2
    uteroglobin related protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_054037.2NP_473378.1  secretoglobin family 3A member 1 isoform a precursor

      See identical proteins and their annotated locations for NP_473378.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as type A) represents the shorter transcript and encodes the longer isoform (a).
      Source sequence(s)
      AF313456, AV578532
      Consensus CDS
      CCDS24619.1
      UniProtKB/Swiss-Prot
      Q920D7
      UniProtKB/TrEMBL
      Q5NCL1
      Related
      ENSMUSP00000043325.4, ENSMUST00000043873.10
    2. NM_170727.2NP_733923.1  secretoglobin family 3A member 1 isoform b

      See identical proteins and their annotated locations for NP_733923.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as type B) differs in the 5' UTR and contains an alternate exon in the 5' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (b) is shorter and has a distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AF313457, AV578532
      Consensus CDS
      CCDS36145.1
      UniProtKB/TrEMBL
      Q8CJC6
      Related
      ENSMUSP00000075387.5, ENSMUST00000076006.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      49554422..49555945
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)