Gpx2 glutathione peroxidase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpx2provided by MGI
Official Full Name: glutathione peroxidase 2provided by MGI
Primary source: MGI:MGI:106609
See related: Ensembl:ENSMUSG00000042808 AllianceGenome:MGI:106609
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GI-GPx; GPx-GI; GSHPx-2; GSHPx-GI
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract in rodents, is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Knockout studies in mice lacking this gene suggest a role for this isozyme in intestinal inflammation and colon cancer development. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 7. [provided by RefSeq, Aug 2017]
Expression: Biased expression in large intestine adult (RPKM 1086.3), small intestine adult (RPKM 241.0) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 C3; 12 33.73 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (76839109..76842328, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (76792335..76795554, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response.
Title: Glutathione peroxidase 2 is a metabolic driver of the tumor immune microenvironment and immune checkpoint inhibitor response.
High glutathione peroxidase 2 expression is associated with radiation induced lung disease.
Title: Basal levels of glutathione peroxidase correlate with onset of radiation induced lung disease in inbred mouse strains.
we propose that ileocolitis in the GPx1/2-double-knockout mice is caused by Nox1, which is induced by TNF
Title: Nox1 causes ileocolitis in mice deficient in glutathione peroxidase-1 and -2.
GPx2 is up-regulated in dysplastic colonic crypts, where it appears to act inhibit apoptosis and, thus, supports tumor development.
Title: Deletion of glutathione peroxidase-2 inhibits azoxymethane-induced colon cancer development.
Candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2, were analyzed.
Title: Analysis of candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2.
it is concluded that GPx2, although supporting tumor growth, inhibits inflammation-mediated tumorigenesis, but the protective effect of selenium does not strictly depend on GPx2 expression
Title: Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply.
study indicates GI-GPx is spatiotemporally expressed in embryonic organs during organogenesis and may also perform a mutual compensatory role with cGPx in protecting embryos and extraembryonic tissues against reactive oxygen species
Title: Differential expression of gastrointestinal glutathione peroxidase (GI-GPx) gene during mouse organogenesis.
Loss of Gpx2 is associated with diet induced severe colitis.
Title: Atherogenic diets exacerbate colitis in mice deficient in glutathione peroxidase.
In GPx2 KO mice, an increase in GPx1 can only partially compensate for GPx2, even under selenium supplementation, indicating that GPx2 is the major antiapoptotic GPx in the colon.
Title: Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice.
Genes encoding the antioxidants GPX2 and GSTO 1-1 are common inflammatory genes expressed upon induction of allergic airway inflammation, and independently of allergic susceptibility.
Title: Glutathione peroxidase-2 protects from allergen-induced airway inflammation in mice.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Markers

AU041318 (e-PCR)
- UniSTS:208161

29.MMHAP85FRB11.seq (e-PCR)
- UniSTS:123879

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione peroxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables glutathione peroxidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phospholipid-hydroperoxide glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid-hydroperoxide glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biological process involved in interaction with symbiont	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to symbiotic bacterium	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within temperature homeostasis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione peroxidase 2

Names: GPx-2; glutathione peroxidase-gastrointestinal; intestinal GPx; phospholipid hydroperoxide glutathione peroxidase GPX2

NP_109602.2

EC 1.11.1.12

EC 1.11.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030677.2 → NP_109602.2 glutathione peroxidase 2

See identical proteins and their annotated locations for NP_109602.2

Status: REVIEWED

Source sequence(s)

AK131940, BX629737, CF612186

Consensus CDS

CCDS25996.1

UniProtKB/Swiss-Prot

Q3V2B2, Q9JHC0

UniProtKB/TrEMBL

A0A0R4J111

Related

ENSMUSP00000081012.5, ENSMUST00000082431.6

Conserved Domains (1) summary

cd00340
Location:7 → 182

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...