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    Matn2 matrilin 2 [ Mus musculus (house mouse) ]

    Gene ID: 17181, updated on 27-Nov-2024

    Summary

    Official Symbol
    Matn2provided by MGI
    Official Full Name
    matrilin 2provided by MGI
    Primary source
    MGI:MGI:109613
    See related
    Ensembl:ENSMUSG00000022324 AllianceGenome:MGI:109613
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crtm2; matrilin-2
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within neurogenesis and response to axon injury. Located in basement membrane. Part of matrilin complex. Is expressed in several structures, including brain; chondrocranium; forelimb; genitourinary system; and spinal cord meninges. Orthologous to human MATN2 (matrilin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 46.5), subcutaneous fat pad adult (RPKM 34.4) and 14 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    15 B3.1; 15 13.98 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (34306827..34436388)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (34306681..34436242)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38594 Neighboring gene STARR-seq mESC enhancer starr_38323 Neighboring gene STARR-seq mESC enhancer starr_38324 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:34167683-34167792 Neighboring gene STARR-seq mESC enhancer starr_38325 Neighboring gene lysosomal-associated protein transmembrane 4B Neighboring gene eukaryotic translation initiation factor 4A2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:34225853-34226040 Neighboring gene RIKEN cDNA 9430069I07 gene Neighboring gene STARR-seq mESC enhancer starr_38326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:34372917-34373070 Neighboring gene predicted gene, 24523 Neighboring gene ribosomal protein L30 Neighboring gene glutamate rich 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102477

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358780.1NP_001345709.1  matrilin-2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC126028, AC133101, AC144632
      Consensus CDS
      CCDS88747.1
      UniProtKB/Swiss-Prot
      E9QPK9, O08746, Q8R542
      UniProtKB/TrEMBL
      Q99K64
      Related
      ENSMUSP00000154040.2, ENSMUST00000227759.2
      Conserved Domains (4) summary
      cd01475
      Location:54276
      vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...
      pfam10393
      Location:911953
      Matrilin_ccoil; Trimeric coiled-coil oligomerization domain of matrilin
      pfam14670
      Location:570605
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:652892
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    2. NM_001427153.1NP_001414082.1  matrilin-2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC133101, AC144632
      UniProtKB/TrEMBL
      A0A2I3BRF3
      Related
      ENSMUSP00000154572.2, ENSMUST00000228570.2
    3. NM_016762.2NP_058042.2  matrilin-2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK138211, AK163818, BY146293
      Consensus CDS
      CCDS37056.1
      UniProtKB/TrEMBL
      Q569V0
      Related
      ENSMUSP00000022947.6, ENSMUST00000022947.7
      Conserved Domains (4) summary
      cd01475
      Location:54276
      vWA_Matrilin; VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. ...
      pfam10393
      Location:892934
      Matrilin_ccoil; Trimeric coiled-coil oligomerization domain of matrilin
      pfam14670
      Location:570605
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:652873
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      34306827..34436388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)