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    Atf1 activating transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 11908, updated on 3-Dec-2024

    Summary

    Official Symbol
    Atf1provided by MGI
    Official Full Name
    activating transcription factor 1provided by MGI
    Primary source
    MGI:MGI:1298366
    See related
    Ensembl:ENSMUSG00000023027 AllianceGenome:MGI:1298366
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Part of ATF1-ATF4 transcription factor complex. Is expressed in several structures, including branchial arch; early conceptus; genitourinary system; limb; and maxillary process. Orthologous to human ATF1 (activating transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 24.0), liver E14 (RPKM 14.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Atf1 in Genome Data Viewer
    Location:
    15 F1; 15 56.22 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (100125729..100159129)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100227859..100261248)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310068J16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3157 Neighboring gene La ribonucleoprotein 4 Neighboring gene STARR-seq mESC enhancer starr_39735 Neighboring gene STARR-positive B cell enhancer mm9_chr15:99890852-99891153 Neighboring gene disco interacting protein 2 homolog B Neighboring gene STARR-seq mESC enhancer starr_39737 Neighboring gene STARR-seq mESC enhancer starr_39738 Neighboring gene STARR-seq mESC enhancer starr_39739 Neighboring gene STARR-seq mESC enhancer starr_39742 Neighboring gene STARR-seq mESC enhancer starr_39744 Neighboring gene STARR-seq mESC enhancer starr_39745 Neighboring gene STARR-seq mESC enhancer starr_39746 Neighboring gene STARR-seq mESC enhancer starr_39747 Neighboring gene transmembrane (C-terminal) protease, serine 12 Neighboring gene predicted gene, 33666

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cAMP/PKA signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inhibition of non-skeletal tissue mineralization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of DNA replication IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cobalt ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to purine-containing compound IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of ATF1-ATF4 transcription factor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ATF1-ATF4 transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ATF4-CREB1 transcription factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclic AMP-dependent transcription factor ATF-1
    Names
    TCR-ATF1
    cAMP-dependent transcription factor ATF-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410369.1NP_001397298.1  cyclic AMP-dependent transcription factor ATF-1

      Status: VALIDATED

      Source sequence(s)
      AC124479
      UniProtKB/Swiss-Prot
      P81269
      UniProtKB/TrEMBL
      Q9CWS2
    2. NM_001410370.1NP_001397299.1  cyclic AMP-dependent transcription factor ATF-1

      Status: VALIDATED

      Source sequence(s)
      AC124479
      UniProtKB/Swiss-Prot
      P81269
      UniProtKB/TrEMBL
      Q9CWS2
    3. NM_007497.4NP_031523.3  cyclic AMP-dependent transcription factor ATF-1

      See identical proteins and their annotated locations for NP_031523.3

      Status: VALIDATED

      Source sequence(s)
      AC124479
      Consensus CDS
      CCDS27832.1
      UniProtKB/Swiss-Prot
      P81269
      UniProtKB/TrEMBL
      Q9CWS2
      Related
      ENSMUSP00000023769.5, ENSMUST00000023769.11
      Conserved Domains (2) summary
      cd14690
      Location:213267
      bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
      pfam02173
      Location:4882
      pKID; pKID domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      100125729..100159129
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)