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    Slc22a2 solute carrier family 22 (organic cation transporter), member 2 [ Mus musculus (house mouse) ]

    Gene ID: 20518, updated on 27-Nov-2024

    Summary

    Official Symbol
    Slc22a2provided by MGI
    Official Full Name
    solute carrier family 22 (organic cation transporter), member 2provided by MGI
    Primary source
    MGI:MGI:1335072
    See related
    Ensembl:ENSMUSG00000040966 AllianceGenome:MGI:1335072
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Oct2; Orct2; mOCT2
    Summary
    Enables several functions, including pyrimidine nucleoside transmembrane transporter activity; toxin transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in cellular detoxification and xenobiotic transport. Acts upstream of or within monoatomic cation transport. Located in apical plasma membrane. Is expressed in several structures, including metanephros; nasal cavity mucosa; nervous system; placenta; and ureter. Human ortholog(s) of this gene implicated in acute kidney failure. Orthologous to human SLC22A2 (solute carrier family 22 member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 64.5), liver adult (RPKM 7.4) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Slc22a2 in Genome Data Viewer
    Location:
    17 A1; 17 8.61 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (12803076..12847376)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (12584189..12628489)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 22 (organic cation transporter), member 3 Neighboring gene RIKEN cDNA C030013G03 gene Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_41857 Neighboring gene solute carrier family 22 (organic cation transporter), member 1 Neighboring gene insulin-like growth factor 2 receptor Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:12938713-12938996 Neighboring gene antisense Igf2r RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Clone Names

    • MGC18339

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-amino acid transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables L-arginine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-arginine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables amine transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables amine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables choline transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables choline transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables efflux transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables efflux transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables monoamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables neurotransmitter transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurotransmitter transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables organic anion transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables organic anion transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables organic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables organic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables organic cation transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables prostaglandin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables prostaglandin transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables putrescine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables putrescine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables pyrimidine nucleoside transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables pyrimidine nucleoside transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables quaternary ammonium group transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables quaternary ammonium group transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables steroid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thiamine transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables thiamine transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables toxin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables toxin transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables xenobiotic transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables xenobiotic transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables xenobiotic transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in L-alpha-amino acid transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-arginine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-arginine import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in acetylcholine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetylcholine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in amine transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amino acid import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular detoxification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular detoxification ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in choline transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in choline transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dopamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in dopamine uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dopamine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epinephrine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in epinephrine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in export across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in export across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histamine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histamine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in histamine uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histamine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within monoatomic cation transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neurotransmitter transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in norepinephrine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in norepinephrine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in norepinephrine uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in norepinephrine uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in organic cation transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within organic cation transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in organic cation transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in prostaglandin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in putrescine transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in putrescine transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in quaternary ammonium group transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in quaternary ammonium group transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in serotonin transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in serotonin transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in serotonin uptake IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thiamine transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in thiamine transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in xenobiotic transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in xenobiotic transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in xenobiotic transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basal plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    solute carrier family 22 member 2
    Names
    organic cation transporter 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355767.1NP_001342696.1  solute carrier family 22 member 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC167817, AK052658, AK143892
      Consensus CDS
      CCDS88992.1
      Related
      ENSMUSP00000156710.2, ENSMUST00000233066.2
      Conserved Domains (1) summary
      TIGR00898
      Location:12525
      2A0119; cation transport protein
    2. NM_013667.3NP_038695.1  solute carrier family 22 member 2 isoform 1

      See identical proteins and their annotated locations for NP_038695.1

      Status: VALIDATED

      Source sequence(s)
      AC167817, AK052658, AK143892, BB739804
      Consensus CDS
      CCDS28392.1
      UniProtKB/Swiss-Prot
      O70577, Q8BWF6, Q8K4X8
      Related
      ENSMUSP00000041186.8, ENSMUST00000046959.9
      Conserved Domains (2) summary
      cd06174
      Location:125492
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:12525
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      12803076..12847376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)