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    Fcrl5 Fc receptor-like 5 [ Mus musculus (house mouse) ]

    Gene ID: 329693, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fcrl5provided by MGI
    Official Full Name
    Fc receptor-like 5provided by MGI
    Primary source
    MGI:MGI:3053558
    See related
    Ensembl:ENSMUSG00000048031 AllianceGenome:MGI:3053558
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fcrh3; mBXMH2
    Summary
    Predicted to enable protein phosphatase binding activity; protein tyrosine kinase binding activity; and transmembrane signaling receptor activity. Acts upstream of or within negative regulation of B cell receptor signaling pathway and negative regulation of release of sequestered calcium ion into cytosol. Located in plasma membrane. Orthologous to several human genes including FCRL5 (Fc receptor like 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 2.7), thymus adult (RPKM 0.2) and 2 other tissues See more
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    Genomic context

    See Fcrl5 in Genome Data Viewer
    Location:
    3 F1; 3 38.19 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87343084..87407985)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87435777..87500678)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31940 Neighboring gene STARR-positive B cell enhancer ABC_E10187 Neighboring gene STARR-positive B cell enhancer ABC_E9215 Neighboring gene STARR-positive B cell enhancer ABC_E3443 Neighboring gene Fc receptor-like 1 Neighboring gene STARR-seq mESC enhancer starr_08155 Neighboring gene predicted gene, 40084 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87239522-87239823 Neighboring gene STARR-seq mESC enhancer starr_08157 Neighboring gene STARR-seq mESC enhancer starr_08158 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87291959-87292260 Neighboring gene predicted gene, 40085 Neighboring gene STARR-positive B cell enhancer ABC_E7919 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87310398-87310698 Neighboring gene STARR-positive B cell enhancer ABC_E7920 Neighboring gene STARR-positive B cell enhancer ABC_E6067 Neighboring gene STARR-positive B cell enhancer ABC_E10189 Neighboring gene STARR-positive B cell enhancer ABC_E6068 Neighboring gene ets variant 3 Neighboring gene ets variant 3-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of B cell receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of establishment of localization in cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of establishment of localization in cell IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of B cell receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of release of sequestered calcium ion into cytosol IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of release of sequestered calcium ion into cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of release of sequestered calcium ion into cytosol IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    Fc receptor-like protein 5
    Names
    BXMAS1-like protein 2
    Fc receptor-like protein 3
    fc receptor homolog 3
    fcR-like protein 5
    moFcRH3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113238.1NP_001106709.1  Fc receptor-like protein 5 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and differs in the 3' UTR compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC163618, AY158090
      Consensus CDS
      CCDS50944.1
      UniProtKB/TrEMBL
      J3QJU0
      Related
      ENSMUSP00000141311.2, ENSMUST00000193229.6
      Conserved Domains (3) summary
      smart00410
      Location:222305
      IG_like; Immunoglobulin like
      pfam13895
      Location:220303
      Ig_2; Immunoglobulin domain
      cl11960
      Location:31114
      Ig; Immunoglobulin domain
    2. NM_183222.3NP_899045.3  Fc receptor-like protein 5 isoform a precursor

      See identical proteins and their annotated locations for NP_899045.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC163618, AY158090
      Consensus CDS
      CCDS50943.1
      UniProtKB/Swiss-Prot
      E9QLI5, Q68SN8, Q80WN2, Q8BJA5
      UniProtKB/TrEMBL
      J3QJU0
      Related
      ENSMUSP00000142210.2, ENSMUST00000194102.6
      Conserved Domains (4) summary
      cd00096
      Location:133137
      Ig; Ig strand B [structural motif]
      pfam13895
      Location:208290
      Ig_2; Immunoglobulin domain
      pfam13927
      Location:310377
      Ig_3; Immunoglobulin domain
      cl11960
      Location:119202
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87343084..87407985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319623.3XP_017175112.1  Fc receptor-like protein 5 isoform X1

      UniProtKB/TrEMBL
      J3QJU0
      Conserved Domains (3) summary
      smart00408
      Location:267328
      IGc2; Immunoglobulin C-2 Type
      pfam13895
      Location:347427
      Ig_2; Immunoglobulin domain
      cl11960
      Location:34112
      Ig; Immunoglobulin domain
    2. XM_006501599.5XP_006501662.1  Fc receptor-like protein 5 isoform X2

      Conserved Domains (2) summary
      pfam13895
      Location:208279
      Ig_2; Immunoglobulin domain
      cl11960
      Location:119202
      Ig; Immunoglobulin domain