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    Etv3 ets variant 3 [ Mus musculus (house mouse) ]

    Gene ID: 27049, updated on 9-Dec-2024

    Summary

    Official Symbol
    Etv3provided by MGI
    Official Full Name
    ets variant 3provided by MGI
    Primary source
    MGI:MGI:1350926
    See related
    Ensembl:ENSMUSG00000003382 AllianceGenome:MGI:1350926
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pe1; METS
    Summary
    Enables DEAD/H-box RNA helicase binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus; negative regulation of cell population proliferation; and negative regulation of transcription by RNA polymerase II. Located in chromatin. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and thymus primordium. Orthologous to human ETV3 (ETS variant transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 11.5), mammary gland adult (RPKM 9.1) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Etv3 in Genome Data Viewer
    Location:
    3 F1; 3 38.19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87432891..87447463)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87525577..87540158)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40084 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87239522-87239823 Neighboring gene Fc receptor-like 5 Neighboring gene STARR-seq mESC enhancer starr_08157 Neighboring gene STARR-seq mESC enhancer starr_08158 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87291959-87292260 Neighboring gene predicted gene, 40085 Neighboring gene STARR-positive B cell enhancer ABC_E7919 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87310398-87310698 Neighboring gene STARR-positive B cell enhancer ABC_E7920 Neighboring gene STARR-positive B cell enhancer ABC_E6067 Neighboring gene STARR-positive B cell enhancer ABC_E10189 Neighboring gene STARR-positive B cell enhancer ABC_E6068 Neighboring gene ets variant 3-like Neighboring gene predicted gene, 25167

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    part_of RNA polymerase II transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription repressor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS translocation variant 3
    Names
    ETS domain transcriptional repressor PE1
    ETS-domain protein
    ets variant gene 3
    mitogenic Ets transcriptional suppressor METS

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083318.3NP_001076787.1  ETS translocation variant 3 isoform 1

      See identical proteins and their annotated locations for NP_001076787.1

      Status: VALIDATED

      Source sequence(s)
      AC139241
      Consensus CDS
      CCDS17453.1
      UniProtKB/Swiss-Prot
      G5E907, Q8R4Z4, Q9QZW1
      UniProtKB/TrEMBL
      Q3U1H6
      Related
      ENSMUSP00000127419.2, ENSMUST00000170036.8
      Conserved Domains (1) summary
      smart00413
      Location:34120
      ETS; erythroblast transformation specific domain
    2. NM_001286844.2NP_001273773.1  ETS translocation variant 3 isoform 1

      See identical proteins and their annotated locations for NP_001273773.1

      Status: VALIDATED

      Source sequence(s)
      AC139241
      Consensus CDS
      CCDS17453.1
      UniProtKB/Swiss-Prot
      G5E907, Q8R4Z4, Q9QZW1
      UniProtKB/TrEMBL
      Q3U1H6
      Conserved Domains (1) summary
      smart00413
      Location:34120
      ETS; erythroblast transformation specific domain
    3. NM_001359750.2NP_001346679.1  ETS translocation variant 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139241
      Conserved Domains (1) summary
      smart00413
      Location:34120
      ETS; erythroblast transformation specific domain
    4. NM_001411078.1NP_001398007.1  ETS translocation variant 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC139241
    5. NM_001411079.1NP_001398008.1  ETS translocation variant 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139241
      UniProtKB/TrEMBL
      D3YVU8
      Related
      ENSMUSP00000114047.2, ENSMUST00000117293.2
    6. NM_001411080.1NP_001398009.1  ETS translocation variant 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC139241
      UniProtKB/TrEMBL
      D3YVU8
    7. NM_012051.5NP_036181.3  ETS translocation variant 3 isoform 1

      See identical proteins and their annotated locations for NP_036181.3

      Status: VALIDATED

      Source sequence(s)
      AC139241
      Consensus CDS
      CCDS17453.1
      UniProtKB/Swiss-Prot
      G5E907, Q8R4Z4, Q9QZW1
      UniProtKB/TrEMBL
      Q3U1H6
      Related
      ENSMUSP00000112915.2, ENSMUST00000119109.8
      Conserved Domains (1) summary
      smart00413
      Location:34120
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87432891..87447463
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)