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    Fcrl2 Fc receptor like 2 [ Mus musculus (house mouse) ]

    Gene ID: 80891, updated on 3-Dec-2024

    Summary

    Official Symbol
    Fcrl2provided by MGI
    Official Full Name
    Fc receptor like 2provided by MGI
    Primary source
    MGI:MGI:1933397
    See related
    Ensembl:ENSMUSG00000015852 AllianceGenome:MGI:1933397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IgSR; Msr2; Fcrh2; Fcrls; IFGP2; MMAN-g; FcRH2sc; moFcRH2sc; 9330158F12; 2810439C17Rik
    Summary
    Predicted to enable protein phosphatase binding activity; signaling adaptor activity; and transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Predicted to be located in cell surface. Predicted to be active in external side of plasma membrane. Orthologous to human FCRL2 (Fc receptor like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 8.9), subcutaneous fat pad adult (RPKM 7.7) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fcrl2 in Genome Data Viewer
    Location:
    3 F1; 3 38.19 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87158318..87171046, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87250736..87263765, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene kirre like nephrin family adhesion molecule 1 Neighboring gene STARR-seq mESC enhancer starr_08147 Neighboring gene VISTA enhancer mm1616 Neighboring gene STARR-seq mESC enhancer starr_08154 Neighboring gene predicted gene 10705 Neighboring gene predicted gene, 31879 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87127693-87127994 Neighboring gene predicted gene, 31940 Neighboring gene CD5 antigen-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (7) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Fc receptor-like protein 2
    Names
    Fc receptor-like S, scavenger receptor
    immunoglobulin scavenger receptor
    macrophage scavenger receptor 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419220.1NP_001406149.1  Fc receptor-like protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC091682
      UniProtKB/TrEMBL
      Q91YK7, Q9EQY5
    2. NM_030707.4NP_109632.2  Fc receptor-like protein 2 precursor

      See identical proteins and their annotated locations for NP_109632.2

      Status: VALIDATED

      Source sequence(s)
      AC091682
      Consensus CDS
      CCDS38471.1
      UniProtKB/TrEMBL
      Q91YK7, Q9EQY5
      Related
      ENSMUSP00000088508.5, ENSMUST00000090986.11
      Conserved Domains (5) summary
      smart00202
      Location:402502
      SR; Scavenger receptor Cys-rich
      smart00409
      Location:316395
      IG; Immunoglobulin
      smart00410
      Location:224302
      IG_like; Immunoglobulin like
      pfam13927
      Location:112181
      Ig_3; Immunoglobulin domain
      cl11960
      Location:1985
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87158318..87171046 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)