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    Chrnb2 cholinergic receptor nicotinic beta 2 subunit [ Mus musculus (house mouse) ]

    Gene ID: 11444, updated on 27-Nov-2024

    Summary

    Official Symbol
    Chrnb2provided by MGI
    Official Full Name
    cholinergic receptor nicotinic beta 2 subunitprovided by MGI
    Primary source
    MGI:MGI:87891
    See related
    Ensembl:ENSMUSG00000027950 AllianceGenome:MGI:87891
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acrb2; Acrb-2; [b]2-nAchR; C030030P04Rik
    Summary
    Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including learning or memory; nervous system development; and regulation of circadian sleep/wake cycle, sleep. Located in external side of plasma membrane. Part of acetylcholine-gated channel complex. Is active in cholinergic synapse; dopaminergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Used to study attention deficit hyperactivity disorder; autism spectrum disorder; and autosomal dominant nocturnal frontal lobe epilepsy 3. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy and autosomal dominant nocturnal frontal lobe epilepsy 3. Orthologous to human CHRNB2 (cholinergic receptor nicotinic beta 2 subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 17.9), cerebellum adult (RPKM 14.9) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Chrnb2 in Genome Data Viewer
    Location:
    3 F1; 3 39.19 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89660755..89671939, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89753448..89764632, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6071 Neighboring gene STARR-positive B cell enhancer ABC_E2081 Neighboring gene phosphomevalonate kinase Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Neighboring gene STARR-seq mESC enhancer starr_08246 Neighboring gene STARR-seq mESC enhancer starr_08247 Neighboring gene STARR-seq mESC enhancer starr_08249 Neighboring gene STARR-positive B cell enhancer ABC_E4555 Neighboring gene adenosine deaminase, RNA-specific Neighboring gene RIKEN cDNA 4632404H12 gene Neighboring gene STARR-positive B cell enhancer ABC_E2082 Neighboring gene ubiquitin-conjugating enzyme E2Q family member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acetylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables acetylcholine-gated monoatomic cation-selective channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables acetylcholine-gated monoatomic cation-selective channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heterocyclic compound binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables quaternary ammonium group binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of B cell proliferation IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within acetylcholine receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in acetylcholine receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within associative learning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within behavioral response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in behavioral response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within central nervous system projection neuron axonogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within conditioned taste aversion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lateral geniculate nucleus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in membrane depolarization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within memory IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuronal action potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuronal action potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within optic nerve morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell proliferation IC
    Inferred by Curator
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of circadian sleep/wake cycle, REM sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of circadian sleep/wake cycle, non-REM sleep IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of dopamine secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of membrane potential IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of synaptic transmission, dopaminergic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to acetylcholine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to nicotine IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to nicotine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to nicotine ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within smooth muscle contraction IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within social behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptic transmission involved in micturition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in synaptic transmission, cholinergic ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vestibulocochlear nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within visual perception IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of acetylcholine-gated channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of acetylcholine-gated channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of acetylcholine-gated channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cholinergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cholinergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in cholinergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in dopaminergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in dopaminergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in presynaptic membrane IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    is_active_in presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    neuronal acetylcholine receptor subunit beta-2
    Names
    acetylcholine receptor beta 2 neural
    cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009602.4NP_033732.2  neuronal acetylcholine receptor subunit beta-2 precursor

      See identical proteins and their annotated locations for NP_033732.2

      Status: VALIDATED

      Source sequence(s)
      AK051742, BC065103, BY123599
      Consensus CDS
      CCDS17515.1
      UniProtKB/Swiss-Prot
      Q8BGP7, Q9ERK7
      UniProtKB/TrEMBL
      Q9R291
      Related
      ENSMUSP00000029562.4, ENSMUST00000029562.5
      Conserved Domains (3) summary
      TIGR00860
      Location:29478
      LIC; Cation transporter family protein
      pfam02931
      Location:29234
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:241477
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      89660755..89671939 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162861.1XP_036018754.1  neuronal acetylcholine receptor subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      Q9R291
      Conserved Domains (3) summary
      TIGR00860
      Location:2418
      LIC; Cation transporter family protein
      cd03558
      Location:95109
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:1174
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    2. XM_030252389.2XP_030108249.1  neuronal acetylcholine receptor subunit beta-2 isoform X1

      UniProtKB/TrEMBL
      Q9R291
      Conserved Domains (3) summary
      TIGR00860
      Location:2418
      LIC; Cation transporter family protein
      cd03558
      Location:95109
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:1174
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))