Htr1d 5-hydroxytryptamine (serotonin) receptor 1D [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Htr1dprovided by MGI
Official Full Name: 5-hydroxytryptamine (serotonin) receptor 1Dprovided by MGI
Primary source: MGI:MGI:96276
See related: Ensembl:ENSMUSG00000070687 AllianceGenome:MGI:96276
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 5-HT1D; Gpcr14; Htr1db; 5-HT-1D
Summary: Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Acts upstream of or within response to toxic substance. Predicted to be active in several cellular components, including dendrite; glutamatergic synapse; and neuronal dense core vesicle. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and integumental system. Orthologous to human HTR1D (5-hydroxytryptamine receptor 1D). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in ovary adult (RPKM 1.0), bladder adult (RPKM 0.8) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 68.74 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (136150835..136171716)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (136423522..136444405)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results suggest that the activation of 5-HT1D receptors selectively enhanced IA via the Gbetagamma of the Go-protein, PKA, and the sequential B-Raf-dependent p38 MAPK signaling cascade.
Title: Serotonin type-1D receptor stimulation of A-type K(+) channel decreases membrane excitability through the protein kinase A- and B-Raf-dependent p38 MAPK pathways in mouse trigeminal ganglion neurons.
5-hydroxytryptamine (serotonin) receptor 1D is a novel marker for gamma motor neurons and that the 5-ht1d receptor is important to receive and relay accurate sensory information in developing and mature spinal cord motor circuits.
Title: Sensorimotor function is modulated by the serotonin receptor 1d, a novel marker for gamma motor neurons.
presence of linkage disequilibrium between each of two polymorphisms of the 5HT1Dbeta receptor gene and obsessive-compulsive disorder
Title: 5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study.
5-HT2B and 1D autoreceptors may play a role in the maintenance of neuron- and neurotransmitter-associated functions.
Title: Reactive oxygen species-dependent TNF-alpha converting enzyme activation through stimulation of 5-HT2B and alpha1D autoreceptors in neuronal cells.
5-Hydroxytryptamine(1B/1D) receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.
Title: 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.
PrPC is a modulator of 5-HT receptor coupling to G-proteins and contributes to the homeostasis of serotonergic neurons
Title: Modulation of serotonergic receptor signaling and cross-talk by prion protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (3)

General gene information

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Markers

Htr1d (e-PCR), detects polymorphism
- UniSTS:143416

Htr1d (e-PCR), detects polymorphism
- UniSTS:143417

UniSTS:143418 (e-PCR)
- UniSTS:143418

Htr1d (e-PCR), detects polymorphism
- UniSTS:143418

AI853647 (e-PCR)
- UniSTS:179100

RH132942 (e-PCR)
- UniSTS:216225

GDB:371366 (e-PCR)
- UniSTS:156842

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled serotonin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled serotonin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled serotonin receptor activity	ISO Inferred from Sequence Orthology more info
enables neurotransmitter receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in intestine smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of locomotion	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to toxic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in vasoconstriction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: 5-hydroxytryptamine receptor 1D

Names: 5-hydroxytryptamine (serotonin) receptor 1D beta; G-protein coupled receptor 14; serotonin receptor 1D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285482.1 → NP_001272411.1 5-hydroxytryptamine receptor 1D

See identical proteins and their annotated locations for NP_001272411.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3 and 4 all encode the same protein.

Source sequence(s)

AI853647, AK082016, AL670673, AW487918, BY728591

Consensus CDS

CCDS18806.1

UniProtKB/Swiss-Prot

Q3ZB48, Q61224, Q61615, Q8BUW7

Related

ENSMUSP00000112402.2, ENSMUST00000121571.8

Conserved Domains (2) summary

cd14964
Location:38 → 62

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 364

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001285483.1 → NP_001272412.1 5-hydroxytryptamine receptor 1D

See identical proteins and their annotated locations for NP_001272412.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.

Source sequence(s)

AI853647, AK082016, AL670673, AW487918

Consensus CDS

CCDS18806.1

UniProtKB/Swiss-Prot

Q3ZB48, Q61224, Q61615, Q8BUW7

Related

ENSMUSP00000112840.2, ENSMUST00000117699.2

Conserved Domains (2) summary

cd14964
Location:38 → 62

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 364

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001285484.2 → NP_001272413.1 5-hydroxytryptamine receptor 1D

See identical proteins and their annotated locations for NP_001272413.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.

Source sequence(s)

AL670673

Consensus CDS

CCDS18806.1

UniProtKB/Swiss-Prot

Q3ZB48, Q61224, Q61615, Q8BUW7

Conserved Domains (2) summary

cd14964
Location:38 → 62

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 364

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
NM_001421106.1 → NP_001408035.1 5-hydroxytryptamine receptor 1D

Status: VALIDATED

Source sequence(s)

AL670673

UniProtKB/Swiss-Prot

Q3ZB48, Q61224, Q61615, Q8BUW7
NM_001421107.1 → NP_001408036.1 5-hydroxytryptamine receptor 1D

Status: VALIDATED

Source sequence(s)

AL670673

UniProtKB/Swiss-Prot

Q3ZB48, Q61224, Q61615, Q8BUW7
NM_008309.5 → NP_032335.2 5-hydroxytryptamine receptor 1D

See identical proteins and their annotated locations for NP_032335.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 all encode the same protein.

Source sequence(s)

AI853647, AK082016, AW487918, BY728591

Consensus CDS

CCDS18806.1

UniProtKB/Swiss-Prot

Q3ZB48, Q61224, Q61615, Q8BUW7

Related

ENSMUSP00000086052.5, ENSMUST00000088677.5

Conserved Domains (2) summary

cd14964
Location:38 → 62

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 364

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

136150835..136171716

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319986.3 → XP_017175475.1 5-hydroxytryptamine receptor 1D isoform X1

UniProtKB/Swiss-Prot

Q3ZB48, Q61224, Q61615, Q8BUW7

Conserved Domains (2) summary

cd14964
Location:38 → 62

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 364

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily