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    F7 coagulation factor VII [ Mus musculus (house mouse) ]

    Gene ID: 14068, updated on 9-Dec-2024

    Summary

    Official Symbol
    F7provided by MGI
    Official Full Name
    coagulation factor VIIprovided by MGI
    Primary source
    MGI:MGI:109325
    See related
    Ensembl:ENSMUSG00000031443 AllianceGenome:MGI:109325
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cf7; FVII
    Summary
    This gene encodes a vitamin K-dependent serine protease that plays a critical role in the extrinsic pathway of blood coagulation. Upon contact with tissue factor III (TF III), the encoded protein forms an activated complex termed TF-FVIIa that initiates the coagulation cascade involving other coagulation factors, ultimately resulting in a fibrin clot. Complete lack of the encoded protein in mice results in in perinatal lethality due to bleeding from normal blood vessels. [provided by RefSeq, Apr 2015]
    Expression
    Biased expression in liver adult (RPKM 49.6), liver E18 (RPKM 7.5) and 3 other tissues See more
    Orthologs
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    Genomic context

    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13075499..13085809)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13025506..13035809)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene mcf.2 transforming sequence-like Neighboring gene STARR-seq mESC enhancer starr_20754 Neighboring gene predicted gene, 53398 Neighboring gene CD24a antigen pseudogene Neighboring gene coagulation factor X Neighboring gene protein Z, vitamin K-dependent plasma glycoprotein Neighboring gene PCI domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Spontaneous (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in circadian rhythm IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of TOR signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of blood coagulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of leukocyte chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of leukocyte chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of leukocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of positive chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to 2,3,7,8-tetrachlorodibenzodioxine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to Thyroid stimulating hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to astaxanthin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to astaxanthin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to carbon dioxide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cholesterol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to genistein IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to growth hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to thyrotropin-releasing hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to thyroxine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to vitamin K IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of serine-type peptidase complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of serine-type peptidase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    coagulation factor VII
    Names
    serum prothrombin conversion accelerator
    NP_034302.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010172.5NP_034302.2  coagulation factor VII preproprotein

      See identical proteins and their annotated locations for NP_034302.2

      Status: VALIDATED

      Source sequence(s)
      AC127308
      Consensus CDS
      CCDS22104.1
      UniProtKB/Swiss-Prot
      P70375, Q61109
      UniProtKB/TrEMBL
      Q542C2
      Related
      ENSMUSP00000033820.4, ENSMUST00000033820.4
      Conserved Domains (5) summary
      smart00020
      Location:193427
      Tryp_SPc; Trypsin-like serine protease
      smart00069
      Location:2485
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:87123
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:194431
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:132168
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13075499..13085809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003947232.2 RNA Sequence