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    Proz protein Z, vitamin K-dependent plasma glycoprotein [ Mus musculus (house mouse) ]

    Gene ID: 66901, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prozprovided by MGI
    Official Full Name
    protein Z, vitamin K-dependent plasma glycoproteinprovided by MGI
    Primary source
    MGI:MGI:1860488
    See related
    Ensembl:ENSMUSG00000031445 AllianceGenome:MGI:1860488
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1300015B06Rik
    Summary
    Predicted to enable serine-type endopeptidase activity. Acts upstream of or within blood coagulation. Located in extracellular region. Is expressed in liver and plasma. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 113.6), liver E18 (RPKM 53.9) and 3 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Proz in Genome Data Viewer
    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13110583..13126026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13060584..13076026)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coagulation factor VII Neighboring gene coagulation factor X Neighboring gene PCI domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1752 Neighboring gene cullin 4A Neighboring gene STARR-seq mESC enhancer starr_20756 Neighboring gene microRNA 7065 Neighboring gene lysosomal-associated membrane protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within blood coagulation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    vitamin K-dependent protein Z

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357219.1NP_001344148.1  vitamin K-dependent protein Z isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC127308
      Consensus CDS
      CCDS90373.1
      UniProtKB/TrEMBL
      Q8CI01
      Related
      ENSMUSP00000147733.2, ENSMUST00000211363.2
      Conserved Domains (4) summary
      smart00069
      Location:2385
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:95122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam14670
      Location:136165
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl27237
      Location:192239
      Trypsin; Trypsin
    2. NM_001357220.1NP_001344149.1  vitamin K-dependent protein Z isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC127308
      UniProtKB/TrEMBL
      Q05CL2
      Conserved Domains (3) summary
      cd00054
      Location:2552
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00089
      Location:122270
      Trypsin; Trypsin
      pfam14670
      Location:6695
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    3. NM_025834.4NP_080110.1  vitamin K-dependent protein Z isoform 1 precursor

      See identical proteins and their annotated locations for NP_080110.1

      Status: VALIDATED

      Source sequence(s)
      AC127308, AK005011, AK008819
      Consensus CDS
      CCDS22105.1
      UniProtKB/Swiss-Prot
      Q9CQW3
      Related
      ENSMUSP00000033822.3, ENSMUST00000033822.4
      Conserved Domains (5) summary
      smart00069
      Location:2385
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:95122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam00089
      Location:192340
      Trypsin; Trypsin
      pfam14670
      Location:136165
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl21584
      Location:192397
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13110583..13126026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508859.5XP_006508922.1  vitamin K-dependent protein Z isoform X2

      Conserved Domains (3) summary
      smart00069
      Location:2385
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:95122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam14670
      Location:136165
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    2. XM_006508858.4XP_006508921.1  vitamin K-dependent protein Z isoform X1

      Conserved Domains (3) summary
      smart00069
      Location:2385
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:95122
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam14670
      Location:136165
      FXa_inhibition; Coagulation Factor Xa inhibitory site