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    Cul4a cullin 4A [ Mus musculus (house mouse) ]

    Gene ID: 99375, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cul4aprovided by MGI
    Official Full Name
    cullin 4Aprovided by MGI
    Primary source
    MGI:MGI:1914487
    See related
    Ensembl:ENSMUSG00000031446 AllianceGenome:MGI:1914487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810470J21Rik
    Summary
    Predicted to enable ubiquitin ligase complex scaffold activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to UV; in utero embryonic development; and ribosome biogenesis. Acts upstream of or within several processes, including negative regulation of granulocyte differentiation; regulation of cell cycle phase transition; and regulation of nucleotide-excision repair. Part of Cul4A-RING E3 ubiquitin ligase complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and musculoskeletal system. Orthologous to human CUL4A (cullin 4A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 25.1), adrenal adult (RPKM 24.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cul4a in Genome Data Viewer
    Location:
    8 A1.1; 8 5.73 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13155623..13197940)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13105623..13147940)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene coagulation factor X Neighboring gene protein Z, vitamin K-dependent plasma glycoprotein Neighboring gene PCI domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E1752 Neighboring gene STARR-seq mESC enhancer starr_20756 Neighboring gene microRNA 7065 Neighboring gene lysosomal-associated membrane protein 1 Neighboring gene GH regulated TBC protein 1 Neighboring gene microRNA 1968

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC36573

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin ligase complex scaffold activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin ligase complex scaffold activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to UV EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of granulocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process via the C-end degron rule pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of Cul4A-RING E3 ubiquitin ligase complex EXP
    Inferred from Experiment
    more info
    PubMed 
    part_of Cul4A-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul4A-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363448.1NP_001350377.1  cullin-4A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment of two consecutive exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC133520
      UniProtKB/TrEMBL
      Q8R1T2
      Conserved Domains (2) summary
      smart00884
      Location:630695
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:89601
      Cullin; Cullin family
    2. NM_001363450.1NP_001350379.1  cullin-4A isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC133520
      UniProtKB/TrEMBL
      Q8R1T2
      Conserved Domains (2) summary
      smart00884
      Location:543608
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:1514
      Cullin; Cullin family
    3. NM_146207.3NP_666319.2  cullin-4A isoform 1

      See identical proteins and their annotated locations for NP_666319.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC133520
      Consensus CDS
      CCDS52485.1
      UniProtKB/Swiss-Prot
      Q3TCH7, Q3THM3, Q91Z44
      Related
      ENSMUSP00000016680.8, ENSMUST00000016680.14
      Conserved Domains (3) summary
      smart00182
      Location:442582
      CULLIN; Cullin
      smart00884
      Location:688753
      Cullin_Nedd8; Cullin protein neddylation domain
      pfam00888
      Location:65659
      Cullin; Cullin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13155623..13197940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)