Got1l1 glutamic-oxaloacetic transaminase 1-like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Got1l1provided by MGI
Official Full Name: glutamic-oxaloacetic transaminase 1-like 1provided by MGI
Primary source: MGI:MGI:1923865
See related: Ensembl:ENSMUSG00000039720 AllianceGenome:MGI:1923865
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700083M11Rik
Summary: Predicted to enable L-aspartate:2-oxoglutarate aminotransferase activity. Predicted to be involved in aspartate biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human GOT1L1 (glutamic-oxaloacetic transaminase 1 like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 22.2) and placenta adult (RPKM 0.7) See more
Orthologs: human all
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Genomic context

Location:: 8 A2; 8 15.92 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (27687487..27713872, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (27197459..27223845, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The rat and human homologs of mouse GOT1L1 are not involved in D-aspartate biosynthesis.
Title: Biosynthesis of D-aspartate in mammals: the rat and human homologs of mouse aspartate racemase are not responsible for the biosynthesis of D-aspartate.
Got1l1 is not the major aspartate racemase and is highly expressed in the testis, but it is not detected in the brain and submandibular gland.
Title: Is D-aspartate produced by glutamic-oxaloacetic transaminase-1 like 1 (Got1l1): a putative aspartate racemase?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-aspartate:2-oxoglutarate aminotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-aspartate:2-oxoglutarate aminotransferase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in aspartate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: putative aspartate aminotransferase, cytoplasmic 2

Names: glutamate oxaloacetate transaminase 1-like protein 1; transaminase A-like protein 1

NP_083950.1

EC 2.6.1.1

XP_006509274.1

EC 2.6.1.1

XP_006509276.1

EC 2.6.1.1

XP_011240469.1

EC 2.6.1.1

XP_036010262.1

EC 2.6.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029674.1 → NP_083950.1 putative aspartate aminotransferase, cytoplasmic 2

See identical proteins and their annotated locations for NP_083950.1

Status: PROVISIONAL

Source sequence(s)

BC052754

Consensus CDS

CCDS22212.1

UniProtKB/Swiss-Prot

Q7TSV6, Q9D9F3

Related

ENSMUSP00000041337.7, ENSMUST00000038174.8

Conserved Domains (1) summary

cl18945
Location:5 → 399

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

27687487..27713872 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509213.5 → XP_006509276.1 putative aspartate aminotransferase, cytoplasmic 2 isoform X2

Conserved Domains (1) summary

cl18945
Location:2 → 359

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_011242167.4 → XP_011240469.1 putative aspartate aminotransferase, cytoplasmic 2 isoform X3

Conserved Domains (1) summary

cl18945
Location:2 → 254

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_006509211.5 → XP_006509274.1 putative aspartate aminotransferase, cytoplasmic 2 isoform X1

See identical proteins and their annotated locations for XP_006509274.1

UniProtKB/Swiss-Prot

Q7TSV6, Q9D9F3

Conserved Domains (1) summary

cl18945
Location:5 → 399

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
XM_036154369.1 → XP_036010262.1 putative aspartate aminotransferase, cytoplasmic 2 isoform X4

Conserved Domains (1) summary

cl18945
Location:1 → 200

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...