Grik4 glutamate receptor, ionotropic, kainate 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Grik4provided by MGI
Official Full Name: glutamate receptor, ionotropic, kainate 4provided by MGI
Primary source: MGI:MGI:95817
See related: Ensembl:ENSMUSG00000032017 AllianceGenome:MGI:95817
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: KA1; KA-1; GluK4; GluRgamma1; 6330551K01Rik
Summary: Predicted to enable kainate selective glutamate receptor activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Located in membrane and synapse. Part of kainate selective glutamate receptor complex. Is active in hippocampal mossy fiber to CA3 synapse; postsynaptic membrane; and presynaptic membrane. Is expressed in brain; retina; and spinal cord. Orthologous to human GRIK4 (glutamate ionotropic receptor kainate type subunit 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in cortex adult (RPKM 1.7), frontal lobe adult (RPKM 1.6) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.1; 9 23.8 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (42431708..42856296, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (42518182..42945000, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cytoplasmic domain of the GluK2 low-affinity subunit stabilizes kainate receptors at synapses. In contrast, the extracellular domain of the GluK4/5 high-affinity subunit synergistically controls the synaptic specificity of kainate receptors through interaction with C1q-like proteins.
Title: Distinct Subunit Domains Govern Synaptic Stability and Specificity of the Kainate Receptor.
These data reveal some requirements for kainate receptor targeting to the synapse, indicating a fundamental role of high affinity kainate receptor subunits in this process.
Title: Synaptic Targeting of Kainate Receptors.
This study demonstrated that mice overexpressing grik4 to directly address circuit dysfunctions associated with ASDs and test specific treatments of autism-related behaviors.
Title: Increased Dosage of High-Affinity Kainate Receptor Gene grik4 Alters Synaptic Transmission and Reproduces Autism Spectrum Disorders Features.
we found that GluK4 is a key mediator of excitotoxic neurodegeneration
Title: The GluK4 kainate receptor subunit regulates memory, mood, and excitotoxic neurodegeneration.
This study demonstrated a clear anxiolytic and antidepressant phenotype associated with ablation of Grik4 and a parallel disruption in hippocampal plasticity.
Title: Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice.
the KA1 KAR subunits are expressed in the SG of the Vc in mice and that the expression level of the KA1 KAR subunit decreases gradually with postnatal development.
Title: Expression of KA1 kainate receptor subunit in the substantia gelatinosa of the trigeminal subnucleus caudalis in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Mit140 (e-PCR), detects polymorphism
- UniSTS:131691

D9Mit254 (e-PCR), detects polymorphism
- UniSTS:159864

NoName (e-PCR)
- UniSTS:224380

Grik4 (e-PCR), detects polymorphism
- UniSTS:545944

M-09357 (e-PCR)
- UniSTS:208364

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kainate selective glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
part_of kainate selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kainate selective glutamate receptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in terminal bouton	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutamate receptor ionotropic, kainate 4

Names: glutamate receptor KA-1; glutamate receptor KA1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175481.6 → NP_780690.2 glutamate receptor ionotropic, kainate 4 precursor

See identical proteins and their annotated locations for NP_780690.2

Status: VALIDATED

Source sequence(s)

AC122449, AC136903, AC140387, AC160123

Consensus CDS

CCDS23089.1

UniProtKB/Swiss-Prot

E9QNA2, Q8BMF5

UniProtKB/TrEMBL

Q148R5

Related

ENSMUSP00000110515.2, ENSMUST00000114865.8

Conserved Domains (2) summary

cd13724
Location:415 → 785

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:24 → 402

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

42431708..42856296 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242383.4 → XP_011240685.1 glutamate receptor ionotropic, kainate 4 isoform X1

See identical proteins and their annotated locations for XP_011240685.1

UniProtKB/Swiss-Prot

E9QNA2, Q8BMF5

UniProtKB/TrEMBL

Q148R5

Conserved Domains (2) summary

cd13724
Location:415 → 785

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:24 → 402

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_030244011.2 → XP_030099871.1 glutamate receptor ionotropic, kainate 4 isoform X1

UniProtKB/Swiss-Prot

E9QNA2, Q8BMF5

UniProtKB/TrEMBL

Q148R5

Conserved Domains (2) summary

cd13724
Location:415 → 785

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:24 → 402

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_030244012.2 → XP_030099872.1 glutamate receptor ionotropic, kainate 4 isoform X1

UniProtKB/Swiss-Prot

E9QNA2, Q8BMF5

UniProtKB/TrEMBL

Q148R5

Conserved Domains (2) summary

cd13724
Location:415 → 785

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:24 → 402

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_006509941.4 → XP_006510004.1 glutamate receptor ionotropic, kainate 4 isoform X1

See identical proteins and their annotated locations for XP_006510004.1

UniProtKB/Swiss-Prot

E9QNA2, Q8BMF5

UniProtKB/TrEMBL

Q148R5

Conserved Domains (2) summary

cd13724
Location:415 → 785

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:24 → 402

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_017313104.3 → XP_017168593.1 glutamate receptor ionotropic, kainate 4 isoform X6

Conserved Domains (1) summary

cd13724
Location:16 → 386

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
XM_036154561.1 → XP_036010454.1 glutamate receptor ionotropic, kainate 4 isoform X3

UniProtKB/TrEMBL

Q148R5

Conserved Domains (2) summary

cl10011
Location:24 → 402

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:425 → 717

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_030244015.2 → XP_030099875.1 glutamate receptor ionotropic, kainate 4 isoform X6

Conserved Domains (1) summary

cd13724
Location:16 → 386

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
XM_030244014.2 → XP_030099874.1 glutamate receptor ionotropic, kainate 4 isoform X6

Conserved Domains (1) summary

cd13724
Location:16 → 386

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily
XM_006509942.5 → XP_006510005.1 glutamate receptor ionotropic, kainate 4 isoform X2

UniProtKB/TrEMBL

Q148R5

Conserved Domains (2) summary

cd13724
Location:381 → 751

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:1 → 368

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_036154562.1 → XP_036010455.1 glutamate receptor ionotropic, kainate 4 isoform X7

Conserved Domains (1) summary

cl21456
Location:1 → 356

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_017313103.3 → XP_017168592.1 glutamate receptor ionotropic, kainate 4 isoform X4

Conserved Domains (2) summary

cd13724
Location:223 → 593

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:1 → 210

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily
XM_006509943.4 → XP_006510006.1 glutamate receptor ionotropic, kainate 4 isoform X5

Conserved Domains (2) summary

cd13724
Location:180 → 550

PBP2_iGluR_kainate_KA1; The ligand-binding domain of the kainate subtype KA1 of ionotropic glutamate receptors, a member of the type 2 periplasmic-binding fold protein superfamily

cl10011
Location:1 → 167

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily