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    Fdx1 ferredoxin 1 [ Mus musculus (house mouse) ]

    Gene ID: 14148, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fdx1provided by MGI
    Official Full Name
    ferredoxin 1provided by MGI
    Primary source
    MGI:MGI:103224
    See related
    Ensembl:ENSMUSG00000032051 AllianceGenome:MGI:103224
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Ferrodoxins are iron-sulfur proteins that facilitate monooxygenase reactions catalyzed by P450 enzymes. The protein encoded by this gene is present in the mitochondrial matrix and transfers electrons from ferredoxin reductase to steroidogenic mitochondrial cytochrome P450 proteins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2014]
    Expression
    Biased expression in adrenal adult (RPKM 1441.7) and ovary adult (RPKM 344.8) See more
    Orthologs
    NEW
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    Genomic context

    See Fdx1 in Genome Data Viewer
    Location:
    9 A5.3; 9 28.62 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (51854323..51874902, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (51943023..51963602, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 20 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:51654007-51654222 Neighboring gene Rho GTPase activating protein 20, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:51674851-51675052 Neighboring gene RIKEN cDNA 4933407I05 gene Neighboring gene predicted gene 6980 Neighboring gene STARR-seq mESC enhancer starr_24133 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene radixin Neighboring gene 40S ribosomal protein S19 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables 2 iron, 2 sulfur cluster binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to NADPH-adrenodoxin reductase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to cholesterol monooxygenase (side-chain-cleaving) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables electron transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables electron transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in NADPH oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in P450-containing electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cellular response to cAMP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to forskolin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cholesterol metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hormone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hormone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial crista ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    adrenodoxin, mitochondrial
    Names
    adrenal ferredoxin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301728.1NP_001288657.1  adrenodoxin, mitochondrial isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC140363, AK148115, BB578768, BX516353, D43689
      Consensus CDS
      CCDS90568.1
      UniProtKB/TrEMBL
      A0A1L1STP5, Q3UG56
      Related
      ENSMUSP00000150434.2, ENSMUST00000214013.2
      Conserved Domains (1) summary
      cl00159
      Location:71150
      fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
    2. NM_007996.2NP_032022.1  adrenodoxin, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_032022.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI050584, BB578768, D43689
      Consensus CDS
      CCDS23178.1
      UniProtKB/Swiss-Prot
      P46656
      UniProtKB/TrEMBL
      Q4FZG2, Q545P3
      Related
      ENSMUSP00000034552.7, ENSMUST00000034552.8
      Conserved Domains (1) summary
      cl00159
      Location:71174
      fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      51854323..51874902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)