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    RRP12 mRNA-binding protein RRP12 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856095, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RRP12
    Official Full Name
    mRNA-binding protein RRP12
    Primary source
    SGD:S000005933
    Locus tag
    YPL012W
    See related
    AllianceGenome:SGD:S000005933; FungiDB:YPL012W; VEuPathDB:YPL012W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleus. Part of 90S preribosome. Orthologous to human RRP12 (ribosomal RNA processing 12 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RRP12 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (529723..533409)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Cip1p Neighboring gene mitochondrial 37S ribosomal protein MRPS16 Neighboring gene Taf3p Neighboring gene coatomer subunit zeta

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Making ribosomes. Fatica A, et al. Curr Opin Cell Biol, 2002 Jun. PMID 12067653
    2. TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export. Vanrobays E, et al. RNA, 2008 Oct. PMID 18755838, Free PMC Article
    3. SUT1p interaction with Cyc8p(Ssn6p) relieves hypoxic genes from Cyc8p-Tup1p repression in Saccharomyces cerevisiae. Régnacq M, et al. Mol Microbiol, 2001 Jun. PMID 11401714
    4. A pre-ribosome-associated HEAT-repeat protein is required for export of both ribosomal subunits. Oeffinger M, et al. Genes Dev, 2004 Jan 15. PMID 14729571, Free PMC Article
    5. Focal accumulation of preribosomes outside the nucleolus during metaphase-anaphase in budding yeast. Moriggi G, et al. RNA, 2017 Sep. PMID 28588079, Free PMC Article

    See all (91) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mRNA-binding protein RRP12
    NP_015313.1
    • Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; also plays a role in the cell cycle and the DNA damage response; contains HEAT-repeats

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      529723..533409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183826.1 → NP_015313.1  TPA: mRNA-binding protein RRP12 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015313.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W400, Q12754, Q7LH12
      UniProtKB/TrEMBL
      A6ZWN4, B3LL50, N1NW64
      Conserved Domains (1) summary
      pfam08161
      Location:414 → 615
      NUC173; NUC173 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12754.1

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