Add1 adducin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Add1provided by MGI
Official Full Name: adducin 1provided by MGI
Primary source: MGI:MGI:87918
See related: Ensembl:ENSMUSG00000029106 AllianceGenome:MGI:87918
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: A structural constituent of cytoskeleton. Involved in cellular response to calcium ion; positive regulation of adherens junction organization; and positive regulation of establishment of endothelial barrier. Acts upstream of or within several processes, including cell volume homeostasis; erythrocyte differentiation; and hemoglobin metabolic process. Located in adherens junction; cytoskeleton; and membrane. Is active in synapse. Colocalizes with plasma membrane. Is expressed in brown fat; cerebellum; cortical plate; and spleen. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; artery disease (multiple); familial combined hyperlipidemia; and gastroschisis. Orthologous to human ADD1 (adducin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in colon adult (RPKM 54.1), cortex adult (RPKM 53.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 B2; 5 17.9 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (34731008..34789652)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (34573664..34632308)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lack of adducin impairs the stability of endothelial adherens and tight junctions and may be required for cAMP-Rac1-mediated endothelial barrier stabilization.
Title: Lack of adducin impairs the stability of endothelial adherens and tight junctions and may be required for cAMP-Rac1-mediated endothelial barrier stabilization.
miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease.
Title: miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer's disease.
Sez6l2 is one of the auxiliary subunits of the AMPA receptor and acts as a scaffolding protein to link GluR1 to ADD. Furthermore, Sez6l2 overexpression upregulates ADD phosphorylation, whereas siRNA-mediated downregulation of Sez612 prevents ADD phosphorylation, suggesting that Sez6l2 modulates AMPA-ADD signal transduction.
Title: Sez6l2 regulates phosphorylation of ADD and neuritogenesis.
Reduction in ADD1 protein in NEK1 mutant mice is associated with hyperphosphorylation of ADD1, thereby preventing the interaction with MYO10 during meiotic spindle formation
Title: NIMA-related kinase 1 (NEK1) regulates meiosis I spindle assembly by altering the balance between α-Adducin and Myosin X.
adducin activity is not essential for actin ring assembly and periodicity but is necessary to control the diameter of both actin rings and axons and actin filament growth within rings.
Title: The Actin-Binding Protein α-Adducin Is Required for Maintaining Axon Diameter.
Targeted deletion of Add1 reveals strain-dependent hyperkyphosis and megaesophagus in c57bl, 129s1 and B6 mice.
Title: Strain-specific hyperkyphosis and megaesophagus in Add1 null mice.
organization of a spectrin-like cytoskeleton is associated with keratinocyte differentiation, and cytoskeleton disruption is mediated by either PKCdelta(Thr505) phosphorylation associated with phosphorylated adducin or due to reduction of endogenous adducin
Title: Disruption of spectrin-like cytoskeleton in differentiating keratinocytes by PKCδ activation is associated with phosphorylated adducin.
These results strongly suggest coordinated expression and phosphorylation of alpha-, beta-, and gamma-adducins as key mechanism underlying synaptic plasticity, motor coordination performance and learning behaviors.
Title: beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits.
Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
Title: Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.
Reorganization of the unique cytoskeletal network defining a primary quiescent T cell is mediated thru the TCR-dependent modification & downregulation of alpha-adducin, resulting in a cytoskeletal shape compatible with T cell effector & memory functions.
Title: Identification of the cytoskeletal regulatory protein alpha-adducin as a target of T cell receptor signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables T cell receptor binding	ISO Inferred from Sequence Orthology more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell volume homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to calcium ion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemoglobin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of adherens junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of adherens junction organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of establishment of endothelial barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of establishment of endothelial barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IMP Inferred from Mutant Phenotype more info	PubMed
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
colocalizes_with plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: alpha-adducin

Names: adducin 1 (alpha); erythrocyte adducin subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024458.4 → NP_001019629.2 alpha-adducin isoform 1

See identical proteins and their annotated locations for NP_001019629.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC115695, AF096839, AF189771, AK054558, CD349465, CF531553

Consensus CDS

CCDS19216.1

UniProtKB/Swiss-Prot

Q9JLE3, Q9QYC0

UniProtKB/TrEMBL

Q8K232

Related

ENSMUSP00000109979.3, ENSMUST00000114340.9

Conserved Domains (2) summary

pfam15310
Location:595 → 701

VAD1-2; Vitamin A-deficiency (VAD) rat model signalling

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001102444.2 → NP_001095914.1 alpha-adducin isoform 3

See identical proteins and their annotated locations for NP_001095914.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the end of an exon and has an alternate exon compared to variant 1 that contains an in-frame stop codon. The resulting isoform (3) contains an internal 31 aa segment not found in isoform 1, but it is still shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC115695, AF096839, AK054558, CF531553

Consensus CDS

CCDS51471.1

UniProtKB/TrEMBL

F8WGR0, Q8K232

Related

ENSMUSP00000001108.5, ENSMUST00000001108.11

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001331080.1 → NP_001318009.1 alpha-adducin isoform 1

Status: VALIDATED

Source sequence(s)

AC115695

Consensus CDS

CCDS19216.1

UniProtKB/Swiss-Prot

Q9JLE3, Q9QYC0

UniProtKB/TrEMBL

Q8K232

Conserved Domains (2) summary

pfam15310
Location:595 → 701

VAD1-2; Vitamin A-deficiency (VAD) rat model signalling

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001331081.1 → NP_001318010.1 alpha-adducin isoform 4

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001331082.1 → NP_001318011.1 alpha-adducin isoform 5

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232

Conserved Domains (2) summary

PHA03307
Location:645 → 766

PHA03307; transcriptional regulator ICP4; Provisional

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001331083.1 → NP_001318012.1 alpha-adducin isoform 6

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232

Conserved Domains (2) summary

PHA03307
Location:616 → 737

PHA03307; transcriptional regulator ICP4; Provisional

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001331084.1 → NP_001318013.1 alpha-adducin isoform 7

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232

Conserved Domains (2) summary

PHA03307
Location:614 → 735

PHA03307; transcriptional regulator ICP4; Provisional

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001331085.1 → NP_001318014.1 alpha-adducin isoform 8

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001331086.1 → NP_001318015.1 alpha-adducin isoform 9

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001331087.1 → NP_001318016.1 alpha-adducin isoform 2

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001420951.1 → NP_001407880.1 alpha-adducin isoform 10

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232
NM_001420952.1 → NP_001407881.1 alpha-adducin isoform 6

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232
NM_001420953.1 → NP_001407882.1 alpha-adducin isoform 11

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232
NM_001420954.1 → NP_001407883.1 alpha-adducin isoform 12

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232
NM_001420955.1 → NP_001407884.1 alpha-adducin isoform 3

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

F8WGR0, Q8K232
NM_001420956.1 → NP_001407885.1 alpha-adducin isoform 13

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

F8WHZ9, Q8K232

Related

ENSMUSP00000052266.7, ENSMUST00000052836.14
NM_001420957.1 → NP_001407886.1 alpha-adducin isoform 9

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232
NM_001420958.1 → NP_001407887.1 alpha-adducin isoform 14

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

E9Q1K3, Q8K232

Related

ENSMUSP00000109974.2, ENSMUST00000114335.8
NM_001420960.1 → NP_001407889.1 alpha-adducin isoform 15

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232
NM_001420961.1 → NP_001407890.1 alpha-adducin isoform 2

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232
NM_001420962.1 → NP_001407891.1 alpha-adducin isoform 4

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232
NM_001420963.1 → NP_001407892.1 alpha-adducin isoform 4

Status: VALIDATED

Source sequence(s)

AC115695

UniProtKB/TrEMBL

Q8K232
NM_013457.4 → NP_038485.1 alpha-adducin isoform 2

See identical proteins and their annotated locations for NP_038485.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) has an alternate exon compared to variant 1 that contains an in-frame stop codon. The resulting isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC115695, AF096839, AK054558, CD349465, CF531553

Consensus CDS

CCDS39069.1

UniProtKB/TrEMBL

Q8K232

Related

ENSMUSP00000109977.3, ENSMUST00000114338.9

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

34731008..34789652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030254071.2 → XP_030109931.1 alpha-adducin isoform X18

UniProtKB/TrEMBL

Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_030254070.2 → XP_030109930.1 alpha-adducin isoform X14

UniProtKB/TrEMBL

Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_006503680.4 → XP_006503743.1 alpha-adducin isoform X16

UniProtKB/TrEMBL

E9Q1K3, Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_006503674.4 → XP_006503737.1 alpha-adducin isoform X5

See identical proteins and their annotated locations for XP_006503737.1

UniProtKB/TrEMBL

Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_006503676.4 → XP_006503739.1 alpha-adducin isoform X7

See identical proteins and their annotated locations for XP_006503739.1

UniProtKB/TrEMBL

Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_006503677.4 → XP_006503740.1 alpha-adducin isoform X10

See identical proteins and their annotated locations for XP_006503740.1

UniProtKB/TrEMBL

F8WGR0, Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_030254067.1 → XP_030109927.1 alpha-adducin isoform X8

UniProtKB/TrEMBL

Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_006503679.3 → XP_006503742.1 alpha-adducin isoform X12

See identical proteins and their annotated locations for XP_006503742.1

UniProtKB/TrEMBL

F8WHZ9, Q8K232

Conserved Domains (1) summary

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_006503669.5 → XP_006503732.1 alpha-adducin isoform X1

See identical proteins and their annotated locations for XP_006503732.1

UniProtKB/TrEMBL

Q8K232

Conserved Domains (2) summary

PHA03307
Location:645 → 766

PHA03307; transcriptional regulator ICP4; Provisional

cl00214
Location:145 → 391

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...