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    Acp1 acid phosphatase 1, soluble [ Mus musculus (house mouse) ]

    Gene ID: 11431, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Acp1provided by MGI
    Official Full Name
    acid phosphatase 1, solubleprovided by MGI
    Primary source
    MGI:MGI:87881
    See related
    Ensembl:ENSMUSG00000044573 AllianceGenome:MGI:87881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Acp-1; Lmptp; LMW-PTP; 4632432E04Rik
    Summary
    Enables acid phosphatase activity. Predicted to be involved in chromatin remodeling. Located in cytosol and sarcolemma. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 16.3), liver E14.5 (RPKM 13.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Acp1 in Genome Data Viewer
    Location:
    12 A2; 12 13.0 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30943325..30961616, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30893326..30911619, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E11506 Neighboring gene transmembrane protein 18 Neighboring gene STARR-seq mESC enhancer starr_31844 Neighboring gene predicted gene, 32320 Neighboring gene STARR-seq mESC enhancer starr_31845 Neighboring gene STARR-positive B cell enhancer ABC_E7128 Neighboring gene ALK and LTK ligand 2 Neighboring gene Sh3 domain YSC-like 1 Neighboring gene STARR-seq mESC enhancer starr_31846 Neighboring gene pyruvate kinase, muscle pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of low-molecular-weight protein tyrosine phosphatase shows limited improvement in glucose tolerance but causes mild cardiac hypertrophy in mice. Jensen-Cody S, et al. Am J Physiol Endocrinol Metab, 2022 Jun 1. PMID 35403438
    2. The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy. Stanford SM, et al. J Cell Physiol, 2021 Sep. PMID 33615467, Free PMC Article
    3. Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading. Rigacci S, et al. J Biol Chem, 2002 Nov 1. PMID 12055185
    4. Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation. Chiarugi P, et al. J Biol Chem, 2002 Oct 4. PMID 12149261
    5. Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP. Fernandes GV, et al. J Cell Biochem, 2014 Jun. PMID 24123071

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy.
      Title: The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy.
    2. Our data show that ablation of Lmptp inhibits pathological cardiac remodelling
      Title: Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.
    3. Data indicate there was no significant change in low molecular weight protein tyrosine phosphatase (LMW-PTP) expression at 30 min or 2 h.
      Title: Osteoblast adhesion dynamics: a possible role for ROS and LMW-PTP.
    4. The expression and activity of Src and low molecular weight protein tyrosine phosphatase (LMWPTP) during osteoblast differentiation was examined and the modulation of Src kinase by LMWPTP was assessed.
      Title: Modulation of Src activity by low molecular weight protein tyrosine phosphatase during osteoblast differentiation.
    5. low M(r) phosphotyrosine protein phosphatase participation in FAK-mediated focal adhesion remodeling.
      Title: Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading.
    6. The formation of LMW-PTP/caveolin-1 complexes is accompanied by modulation of the enzyme activities, and the inhibitory effect elicited against IF1 is stronger than that against IF2
      Title: Low molecular weight protein tyrosine phosphatase and caveolin-1: interaction and isoenzyme-dependent regulation.
    7. plays a role on PDGF receptor signaling and controls PDGF-r kinase activity through TYR-857 dephosphorylation
      Title: Insight into the role of low molecular weight phosphotyrosine phosphatase (LMW-PTP) on platelet-derived growth factor receptor (PDGF-r) signaling. LMW-PTP controls PDGF-r kinase activity through TYR-857 dephosphorylation.
    8. The redox-dependent enhancement of Grb2 recruitment to LMW-PTP ultimately leads to an improvement of ERK activation, likely triggering a prosurvival signal against the oxidant environment.
      Title: A novel redox-based switch: LMW-PTP oxidation enhances Grb2 binding and leads to ERK activation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC103115, MGC132904

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acid phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    low molecular weight phosphotyrosine protein phosphatase
    Names
    LMW-PTPase
    low molecular weight cytosolic acid phosphatase
    NP_001103709.1
    NP_067305.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110239.1 → NP_001103709.1  low molecular weight phosphotyrosine protein phosphatase isoform 1

      See identical proteins and their annotated locations for NP_001103709.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1, also known as IF2).
      Source sequence(s)
      AC160932, AK014603, AK152429
      Consensus CDS
      CCDS49045.1
      UniProtKB/TrEMBL
      Q561M1
      Related
      ENSMUSP00000073686.6, ENSMUST00000074038.7
      Conserved Domains (1) summary
      cd16343
      Location:7 → 155
      LMWPTP; Low molecular weight protein tyrosine phosphatase

    2. NM_021330.4 → NP_067305.2  low molecular weight phosphotyrosine protein phosphatase isoform 2

      See identical proteins and their annotated locations for NP_067305.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2, also known as IF1) is the same length as isoform 1 but differs at an internal region, compared to isoform 1.
      Source sequence(s)
      AC160932, AK082955
      Consensus CDS
      CCDS36427.1
      UniProtKB/Swiss-Prot
      O88739, O88740, Q9D358, Q9QWF5
      UniProtKB/TrEMBL
      Q4VAI2
      Related
      ENSMUSP00000106509.4, ENSMUST00000062740.15
      Conserved Domains (1) summary
      cd00115
      Location:7 → 155
      LMWPc; Low molecular weight phosphatase family;

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      30943325..30961616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_381176.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D358.3 GenPept UniProtKB/Swiss-Prot:Q9D358

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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