Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc2a1provided by MGI
Official Full Name: solute carrier family 2 (facilitated glucose transporter), member 1provided by MGI
Primary source: MGI:MGI:95755
See related: Ensembl:ENSMUSG00000028645 AllianceGenome:MGI:95755
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GT1; Glut1; Glut-1; M100200; Rgsc200
Summary: Enables D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and fucose transmembrane transporter activity. Involved in D-glucose transmembrane transport and dehydroascorbic acid transport. Acts upstream of or within cellular response to glucose starvation. Located in several cellular components, including basolateral plasma membrane; nucleus; and photoreceptor inner segment. Is active in Golgi membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Used to study glucose transporter type 1 deficiency syndrome 1. Human ortholog(s) of this gene implicated in epilepsy (multiple); glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14.5 (RPKM 161.1), placenta adult (RPKM 140.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.1; 4

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (118966001..118994527)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (119108745..119137330)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis.
Title: Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis.
GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy.
Title: GLUT1 overexpression enhances CAR T cell metabolic fitness and anti-tumor efficacy.
Expression of the monocarboxylate transporter MCT1 is required for virus-specific mouse CD8[+] T cell memory development.
Title: Expression of the monocarboxylate transporter MCT1 is required for virus-specific mouse CD8(+) T cell memory development.
GLUT1 Promotes NLRP3 Inflammasome Activation of Airway Epithelium in Lipopolysaccharide-Induced Acute Lung Injury.
Title: GLUT1 Promotes NLRP3 Inflammasome Activation of Airway Epithelium in Lipopolysaccharide-Induced Acute Lung Injury.
GLUT1 regulates the release of VEGF-A in the alveolar epithelium of lipopolysaccharide-induced acute lung injury.
Title: GLUT1 regulates the release of VEGF-A in the alveolar epithelium of lipopolysaccharide-induced acute lung injury.
GLUT1-mediated glucose import in B cells is critical for anaplerotic balance and humoral immunity.
Title: GLUT1-mediated glucose import in B cells is critical for anaplerotic balance and humoral immunity.
GLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma.
Title: GLUT1 mediates the release of HMGB1 from airway epithelial cells in mixed granulocytic asthma.
GLUT1 contributes to impaired epithelial tight junction in the late phase of acute lung injury.
Title: GLUT1 contributes to impaired epithelial tight junction in the late phase of acute lung injury.
Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
Title: Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity.
Title: Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity.

Submit: New GeneRIF Correction See all GeneRIFs (136)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc2a1 (e-PCR), detects polymorphism
- UniSTS:547329

NoName (e-PCR)
- UniSTS:225027

Slc2a1 (e-PCR), detects polymorphism
- UniSTS:144421

Slc2a1 (e-PCR), detects polymorphism
- UniSTS:144422

Slc2a1 (e-PCR), detects polymorphism
- UniSTS:516693

PMC162224P1 (e-PCR)
- UniSTS:271465

Slc2a1 (e-PCR), detects polymorphism
- UniSTS:496786

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables D-glucose transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables D-glucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables D-glucose transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables dehydroascorbic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables dehydroascorbic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fucose transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables xenobiotic transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
involved_in D-glucose import	IEA Inferred from Electronic Annotation more info
involved_in D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in D-glucose import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in D-glucose import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in D-glucose transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cellular hyperosmotic response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
involved_in dehydroascorbic acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in dehydroascorbic acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dehydroascorbic acid transport	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in fucose transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in photoreceptor cell maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to Thyroglobulin triiodothyronine	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to insulin	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info
involved_in transport across blood-brain barrier	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cortical actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in female germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in female pronucleus	IDA Inferred from Direct Assay more info	PubMed
part_of glucose transporter complex	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IEA Inferred from Electronic Annotation more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in photoreceptor inner segment	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: solute carrier family 2, facilitated glucose transporter member 1

Names: glucose transporter type 1, erythrocyte/brain; solute carrier family 2, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001424864.1 → NP_001411793.1 solute carrier family 2, facilitated glucose transporter member 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL606975

UniProtKB/TrEMBL

Q3TD17
NM_011400.4 → NP_035530.2 solute carrier family 2, facilitated glucose transporter member 1 isoform 1

See identical proteins and their annotated locations for NP_035530.2

Status: VALIDATED

Source sequence(s)

AL606975

Consensus CDS

CCDS18569.1

UniProtKB/Swiss-Prot

P17809, Q61608, Q6GTI3

UniProtKB/TrEMBL

Q3TD17

Related

ENSMUSP00000030398.4, ENSMUST00000030398.10

Conserved Domains (2) summary

cd06174
Location:62 → 450

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

pfam00083
Location:19 → 467

Sugar_tr; Sugar (and other) transporter