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    Scml4 Scm polycomb group protein like 4 [ Mus musculus (house mouse) ]

    Gene ID: 268297, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Scml4provided by MGI
    Official Full Name
    Scm polycomb group protein like 4provided by MGI
    Primary source
    MGI:MGI:2446140
    See related
    Ensembl:ENSMUSG00000044770 AllianceGenome:MGI:2446140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mFLJ00197; 9330161D17
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in dorsal root ganglion. Orthologous to human SCML4 (Scm polycomb group protein like 4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in spleen adult (RPKM 3.2), thymus adult (RPKM 2.9) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Scml4 in Genome Data Viewer
    Location:
    10 B2; 10 22.89 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (42736314..42836778)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (42858077..42960782)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene SEC63 homolog, protein translocation regulator Neighboring gene STARR-seq mESC enhancer starr_26495 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:42582153-42582336 Neighboring gene predicted gene, 53623 Neighboring gene predicted gene, 34006 Neighboring gene STARR-seq mESC enhancer starr_26496 Neighboring gene STARR-positive B cell enhancer ABC_E6835 Neighboring gene STARR-seq mESC enhancer starr_26499 Neighboring gene STARR-positive B cell enhancer mm9_chr10:42709746-42710047 Neighboring gene predicted gene, 51402 Neighboring gene predicted gene 5079 Neighboring gene STARR-seq mESC enhancer starr_26500 Neighboring gene sine oculis binding protein Neighboring gene predicted gene, 47815

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fatty Acids Support the Fitness and Functionality of Tumor-Resident CD8+ T Cells by Maintaining SCML4 Expression. Feng M, et al. Cancer Res, 2023 Oct 13. PMID 37610617
    2. The Calcium Channel Subunit Alpha2delta2 Suppresses Axon Regeneration in the Adult CNS. Tedeschi A, et al. Neuron, 2016 Oct 19. PMID 27720483
    3. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
    4. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC49264

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sex comb on midleg-like protein 4
    Names
    sex comb on midleg-like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359264.1 → NP_001346193.1  sex comb on midleg-like protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC125206, AI510183, AK034171, AK047972, CB521445
      Conserved Domains (3) summary
      cd09578
      Location:416 → 487
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      pfam12140
      Location:177 → 285
      SLED; SLED domain
      pfam17208
      Location:83 → 142
      RBR; RNA binding Region

    2. NM_001359265.1 → NP_001346194.1  sex comb on midleg-like protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC125206, AI510183, AK034171, AK047972, CB521445
      Consensus CDS
      CCDS87999.1
      Related
      ENSMUSP00000101133.2, ENSMUST00000105494.8
      Conserved Domains (2) summary
      cd09578
      Location:276 → 347
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      pfam12140
      Location:37 → 145
      SLED; SLED domain

    3. NM_001359266.1 → NP_001346195.1  sex comb on midleg-like protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC125206, AK034171
      Consensus CDS
      CCDS87998.1
      UniProtKB/TrEMBL
      D3Z791
      Related
      ENSMUSP00000101134.2, ENSMUST00000105495.8
      Conserved Domains (2) summary
      pfam12140
      Location:95 → 162
      SLED; SLED domain
      pfam17208
      Location:1 → 60
      RBR; RNA binding Region

    4. NM_172938.3 → NP_766526.3  sex comb on midleg-like protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125206, AK034171, AK220309
      Consensus CDS
      CCDS23816.1
      UniProtKB/Swiss-Prot
      Q3TA16, Q3V358, Q5DU61, Q80VG1, Q8CC08
      Related
      ENSMUSP00000053157.8, ENSMUST00000063063.14
      Conserved Domains (3) summary
      cd09578
      Location:334 → 405
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      smart00454
      Location:337 → 405
      SAM; Sterile alpha motif
      pfam12140
      Location:95 → 204
      DUF3588; Protein of unknown function (DUF3588)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      42736314..42836778
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155790.1 → XP_036011683.1  sex comb on midleg-like protein 4 isoform X3

      Conserved Domains (2) summary
      pfam12140
      Location:177 → 244
      SLED; SLED domain
      pfam17208
      Location:83 → 142
      RBR; RNA binding Region

    2. XM_006512752.5 → XP_006512815.1  sex comb on midleg-like protein 4 isoform X2

      Conserved Domains (3) summary
      cd09578
      Location:351 → 422
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      pfam12140
      Location:177 → 246
      SLED; SLED domain
      pfam17208
      Location:83 → 142
      RBR; RNA binding Region

    3. XM_006512751.5 → XP_006512814.1  sex comb on midleg-like protein 4 isoform X1

      Conserved Domains (3) summary
      cd09578
      Location:381 → 452
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      pfam12140
      Location:142 → 250
      SLED; SLED domain
      pfam17208
      Location:48 → 107
      RBR; RNA binding Region

    4. XM_017313950.3 → XP_017169439.1  sex comb on midleg-like protein 4 isoform X4

      UniProtKB/TrEMBL
      Q3UR41
      Conserved Domains (2) summary
      cd09578
      Location:92 → 163
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      pfam04484
      Location:36 → 109
      QWRF; QWRF family

    5. XM_006512757.4 → XP_006512820.1  sex comb on midleg-like protein 4 isoform X4

      UniProtKB/TrEMBL
      Q3UR41
      Conserved Domains (2) summary
      cd09578
      Location:92 → 163
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      pfam04484
      Location:36 → 109
      QWRF; QWRF family

    6. XM_006512755.4 → XP_006512818.1  sex comb on midleg-like protein 4 isoform X4

      UniProtKB/TrEMBL
      Q3UR41
      Conserved Domains (2) summary
      cd09578
      Location:92 → 163
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      pfam04484
      Location:36 → 109
      QWRF; QWRF family

    7. XM_006512756.5 → XP_006512819.1  sex comb on midleg-like protein 4 isoform X4

      UniProtKB/TrEMBL
      Q3UR41
      Conserved Domains (2) summary
      cd09578
      Location:92 → 163
      SAM_Scm; SAM domain of Scm proteins of Polycomb group
      pfam04484
      Location:36 → 109
      QWRF; QWRF family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VG1.2 GenPept UniProtKB/Swiss-Prot:Q80VG1

    Gene LinkOut

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