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    Mpg N-methylpurine-DNA glycosylase [ Mus musculus (house mouse) ]

    Gene ID: 268395, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mpgprovided by MGI
    Official Full Name
    N-methylpurine-DNA glycosylaseprovided by MGI
    Primary source
    MGI:MGI:97073
    See related
    Ensembl:ENSMUSG00000020287 AllianceGenome:MGI:97073
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aag; APNG; Mid1; 9830006D05
    Summary
    Enables alkylbase DNA N-glycosylase activity. Acts upstream of or within base-excision repair. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; musculature; and placenta. Orthologous to human MPG (N-methylpurine DNA glycosylase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.1), genital fat pad adult (RPKM 7.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mpg in Genome Data Viewer
    Location:
    11 A4; 11 18.83 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32176505..32182702)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32226505..32232702)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E730 Neighboring gene small nuclear ribonucleoprotein 25 (U11/U12) Neighboring gene rhomboid 5 homolog 1 Neighboring gene STARR-positive B cell enhancer ABC_E11473 Neighboring gene alpha-globin locus regulatory region Neighboring gene nitrogen permease regulator-like 3 Neighboring gene hemoglobin X, alpha-like embryonic chain in Hba complex Neighboring gene hemoglobin alpha, adult chain 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-3-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-3-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-5-methylcytosine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-7-methyladenine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-7-methylguanine glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables alkylbase DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables alkylbase DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alkylbase DNA N-glycosylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in base-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within base-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial nucleoid IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA-3-methyladenine glycosylase
    Names
    3-alkyladenine DNA glycosylase
    3-methyladenine DNA glycosidase
    3-methyladenine DNA glycosylase
    ADPG
    alkylpurine-DNA-N-glycosylase
    NP_034952.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010822.4NP_034952.2  DNA-3-methyladenine glycosylase

      See identical proteins and their annotated locations for NP_034952.2

      Status: VALIDATED

      Source sequence(s)
      AL929446
      Consensus CDS
      CCDS24520.1
      UniProtKB/Swiss-Prot
      A2AVE7, Q04841, Q64182
      UniProtKB/TrEMBL
      Q3U1C9
      Related
      ENSMUSP00000020528.8, ENSMUST00000020528.14
      Conserved Domains (1) summary
      cd00540
      Location:110307
      AAG; Alkyladenine DNA glycosylase catalyzes the first step in base excision repair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      32176505..32182702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)