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    Crygs crystallin, gamma S [ Mus musculus (house mouse) ]

    Gene ID: 12970, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crygsprovided by MGI
    Official Full Name
    crystallin, gamma Sprovided by MGI
    Primary source
    MGI:MGI:1298216
    See related
    Ensembl:ENSMUSG00000033501 AllianceGenome:MGI:1298216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Opj; rncat
    Summary
    A structural constituent of eye lens. Acts upstream of or within lens development in camera-type eye and morphogenesis of an epithelium. Is expressed in alimentary system; eye; and genitourinary system. Used to study cataract 20 multiple types. Human ortholog(s) of this gene implicated in cataract 20 multiple types. Orthologous to human CRYGS (crystallin gamma S). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Crygs in Genome Data Viewer
    Location:
    16 B1; 16 13.66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22623953..22630160, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22805203..22811410, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene diacylglycerol kinase, gamma Neighboring gene STARR-seq mESC enhancer starr_40416 Neighboring gene STARR-positive B cell enhancer mm9_chr16:22633282-22633583 Neighboring gene microRNA 6362 Neighboring gene STARR-seq mESC enhancer starr_40417 Neighboring gene STARR-positive B cell enhancer ABC_E5532 Neighboring gene ribosomal protein SA pseudogene Neighboring gene predicted gene, 30416 Neighboring gene TBCC domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E484 Neighboring gene DnaJ heat shock protein family (Hsp40) member B11 Neighboring gene predicted gene, 30505

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    gamma-crystallin S
    Names
    beta-crystallin S
    opacity due to poor secondary fiber cell junction
    recessive nuclear cataract

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009967.2NP_034097.1  gamma-crystallin S

      See identical proteins and their annotated locations for NP_034097.1

      Status: VALIDATED

      Source sequence(s)
      AK143060, CT571248
      Consensus CDS
      CCDS28069.1
      UniProtKB/Swiss-Prot
      O35486
      UniProtKB/TrEMBL
      Q3UPY3
      Related
      ENSMUSP00000043588.5, ENSMUST00000040592.6
      Conserved Domains (2) summary
      smart00247
      Location:784
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:95176
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22623953..22630160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521755.2XP_006521818.1  gamma-crystallin S isoform X1

      Conserved Domains (2) summary
      pfam00030
      Location:37118
      Crystall; Beta/Gamma crystallin
      cl02528
      Location:126
      Crystall; Beta/Gamma crystallin