U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Crygf crystallin, gamma F [ Mus musculus (house mouse) ]

    Gene ID: 12969, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crygfprovided by MGI
    Official Full Name
    crystallin, gamma Fprovided by MGI
    Primary source
    MGI:MGI:88526
    See related
    Ensembl:ENSMUSG00000025945 AllianceGenome:MGI:88526
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Len-2; Cryg-2; DGcry-2; 3110001K11Rik
    Summary
    Predicted to be a structural constituent of eye lens. Acts upstream of or within eye development. Is expressed in embryo; eye; head; lens; and retina. Human ortholog(s) of this gene implicated in cataract 4 multiple types and cataract 7. Orthologous to human CRYGD (crystallin gamma D). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Crygf in Genome Data Viewer
    Location:
    1 C3; 1 33.31 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (65965681..65967470)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (65926522..65928311)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57567 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 16B pseudogene Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01181 Neighboring gene STARR-seq mESC enhancer starr_01182 Neighboring gene cell growth-regulating nucleolar protein Neighboring gene predicted gene 8812

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (other) (1)  1 citation
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of eye lens IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of eye lens IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lens development in camera-type eye IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in visual perception IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in visual perception ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    gamma-crystallin F
    Names
    gamma-F-crystallin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360779.1NP_001347708.1  gamma-crystallin F isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK013953, CA326162, CA452192
      Consensus CDS
      CCDS87841.1
      UniProtKB/TrEMBL
      E9Q3I1
      Related
      ENSMUSP00000109661.3, ENSMUST00000114027.3
      Conserved Domains (1) summary
      smart00247
      Location:382
      XTALbg; Beta/gamma crystallins
    2. NM_027010.3NP_081286.1  gamma-crystallin F isoform 1

      See identical proteins and their annotated locations for NP_081286.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK013953, CA326162
      Consensus CDS
      CCDS15018.1
      UniProtKB/Swiss-Prot
      Q9CXV3
      UniProtKB/TrEMBL
      A2RTH4
      Related
      ENSMUSP00000027082.5, ENSMUST00000027082.11
      Conserved Domains (2) summary
      smart00247
      Location:382
      XTALbg; Beta/gamma crystallins
      pfam00030
      Location:89170
      Crystall; Beta/Gamma crystallin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      65965681..65967470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)