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    Lim2 lens intrinsic membrane protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 233187, updated on 27-Nov-2024

    Summary

    Official Symbol
    Lim2provided by MGI
    Official Full Name
    lens intrinsic membrane protein 2provided by MGI
    Primary source
    MGI:MGI:104698
    See related
    Ensembl:ENSMUSG00000118560 AllianceGenome:MGI:104698
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    To3; MP17; MP18; MP19; MP20; 4833403J20
    Summary
    Predicted to be a structural constituent of eye lens. Acts upstream of or within lens development in camera-type eye. Predicted to be located in vesicle. Predicted to be active in plasma membrane. Is expressed in embryo; head; inter-parietal bone primordium; and lens. Used to study cataract and cataract 19 multiple types. Human ortholog(s) of this gene implicated in cataract and cataract 19 multiple types. Orthologous to human LIM2 (lens intrinsic membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Lim2 in Genome Data Viewer
    Location:
    7 B3; 7 28.25 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43079523..43085420)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43430099..43435996)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene sialic acid binding Ig-like lectin G Neighboring gene predicted gene, 38999 Neighboring gene natural killer cell group 7 sequence Neighboring gene STARR-positive B cell enhancer ABC_E9689 Neighboring gene claudin domain containing 2 Neighboring gene electron transferring flavoprotein, beta polypeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of eye lens TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in bicellular tight junction TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lens fiber membrane intrinsic protein
    Names
    total opacity 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177693.4NP_808361.1  lens fiber membrane intrinsic protein

      See identical proteins and their annotated locations for NP_808361.1

      Status: VALIDATED

      Source sequence(s)
      AK029354, CK780500, CX734633
      Consensus CDS
      CCDS21168.1
      UniProtKB/Swiss-Prot
      P56563, Q0VEF3, Q3TNV8, Q99PA6
      UniProtKB/TrEMBL
      Q569M6
      Related
      ENSMUSP00000004732.6, ENSMUST00000004732.7
      Conserved Domains (1) summary
      pfam00822
      Location:1157
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      43079523..43085420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)