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    Hba-a1 hemoglobin alpha, adult chain 1 [ Mus musculus (house mouse) ]

    Gene ID: 15122, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hba-a1provided by MGI
    Official Full Name
    hemoglobin alpha, adult chain 1provided by MGI
    Primary source
    MGI:MGI:96015
    See related
    Ensembl:ENSMUSG00000069919 AllianceGenome:MGI:96015
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hba; Hba1; Hbat1
    Summary
    Predicted to enable several functions, including amyloid-beta binding activity; heme binding activity; and oxygen binding activity. Predicted to contribute to haptoglobin binding activity and peroxidase activity. Involved in response to stilbenoid. Acts upstream of or within erythrocyte development; in utero embryonic development; and response to bacterium. Located in myelin sheath. Part of hemoglobin complex. Is expressed in several structures, including blood vessel; early conceptus; hematopoietic system; liver; and visceral pericardium. Human ortholog(s) of this gene implicated in Heinz body anemia; alpha thalassemia; familial erythrocytosis 7; and hemoglobin H disease. Orthologous to human HBA1 (hemoglobin subunit alpha 1) and HBA2 (hemoglobin subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 54307.5), heart adult (RPKM 17770.4) and 4 other tissues See more
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    Genomic context

    See Hba-a1 in Genome Data Viewer
    Location:
    11 A4; 11 18.86 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (32233672..32234486)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (32283672..32284486)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene alpha-globin locus regulatory region Neighboring gene N-methylpurine-DNA glycosylase Neighboring gene nitrogen permease regulator-like 3 Neighboring gene hemoglobin X, alpha-like embryonic chain in Hba complex Neighboring gene hemoglobin, theta 1B Neighboring gene hemoglobin alpha, adult chain 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to haptoglobin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to haptoglobin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables organic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxygen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxygen binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to oxygen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxygen carrier activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oxygen carrier activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to peroxidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carbon dioxide transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within erythrocyte development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in hydrogen peroxide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in nitric oxide transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in oxygen transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to stilbenoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    part_of haptoglobin-hemoglobin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of haptoglobin-hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of hemoglobin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of hemoglobin complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of hemoglobin complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of hemoglobin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in myelin sheath HDA PubMed 

    General protein information

    Preferred Names
    hemoglobin subunit alpha
    Names
    alpha 1 globin
    alpha globin 1
    alpha-globin
    haemaglobin alpha 1
    hemoglobin alpha chain

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008218.2NP_032244.2  hemoglobin subunit alpha

      See identical proteins and their annotated locations for NP_032244.2

      Status: VALIDATED

      Source sequence(s)
      AK011055, BC043020
      Consensus CDS
      CCDS24523.1
      UniProtKB/Swiss-Prot
      P01942
      UniProtKB/TrEMBL
      A8DUV3, Q8BPF4, Q91VB8, Q9CWS5, Q9CY06
      Related
      ENSMUSP00000090897.4, ENSMUST00000093209.4
      Conserved Domains (1) summary
      cd08927
      Location:3142
      Hb-alpha_like; Hemoglobin alpha, zeta, mu, theta, and related Hb subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      32233672..32234486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)