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    Mn1 meningioma 1 [ Mus musculus (house mouse) ]

    Gene ID: 433938, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mn1provided by MGI
    Official Full Name
    meningioma 1provided by MGI
    Primary source
    MGI:MGI:1261813
    See related
    Ensembl:ENSMUSG00000070576 AllianceGenome:MGI:1261813
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Acts upstream of or within intramembranous ossification. Predicted to be located in nucleus. Is expressed in several structures, including brain; limb long bone; palatal shelf; tarsus; and ventral grey horn. Human ortholog(s) of this gene implicated in familial meningioma; meningioma; and myeloid leukemia. Orthologous to human MN1 (MN1 proto-oncogene, transcriptional regulator). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 15.7), CNS E14 (RPKM 12.6) and 21 other tissues See more
    Orthologs
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    Genomic context

    See Mn1 in Genome Data Viewer
    Location:
    5 F; 5 53.86 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (111565145..111604890)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (111417300..111457030)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene predicted gene, 35628 Neighboring gene phosphatidylinositol transfer protein, beta Neighboring gene predicted gene, 36027 Neighboring gene predicted gene, 42155 Neighboring gene predicted gene, 42154 Neighboring gene cardiac ischemia reperfusion associated p53 interacting lncRNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    transcriptional activator MN1
    Names
    probable tumor suppressor protein MN1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081235.3NP_001074704.1  transcriptional activator MN1

      Status: VALIDATED

      Source sequence(s)
      AC122226, AC124749
      Consensus CDS
      CCDS39214.1
      UniProtKB/Swiss-Prot
      D3YWE6
      Related
      ENSMUSP00000092034.5, ENSMUST00000094463.5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      111565145..111604890
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)