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    Fzd5 frizzled class receptor 5 [ Mus musculus (house mouse) ]

    Gene ID: 14367, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fzd5provided by MGI
    Official Full Name
    frizzled class receptor 5provided by MGI
    Primary source
    MGI:MGI:108571
    See related
    Ensembl:ENSMUSG00000045005 AllianceGenome:MGI:108571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fz5; Fz-5; mFz5; 5330434N09Rik
    Summary
    Enables Wnt-protein binding activity. Involved in camera-type eye development; canonical Wnt signaling pathway; and positive regulation of cytokine production. Acts upstream of or within several processes, including columnar/cuboidal epithelial cell maturation; embryonic organ development; and positive regulation of macromolecule metabolic process. Located in several cellular components, including Golgi apparatus; bicellular tight junction; and perinuclear region of cytoplasm. Colocalizes with early endosome. Is expressed in several structures, including alimentary system; early conceptus; embryo ectoderm; eye; and genitourinary system. Orthologous to human FZD5 (frizzled class receptor 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in colon adult (RPKM 30.4), large intestine adult (RPKM 20.0) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fzd5 in Genome Data Viewer
    Location:
    1 C2; 1 32.74 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (64769717..64776907, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (64730558..64737750, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2810408I11 gene Neighboring gene STARR-positive B cell enhancer ABC_E983 Neighboring gene STARR-positive B cell enhancer ABC_E9466 Neighboring gene cyclin Y-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E11072 Neighboring gene STARR-seq mESC enhancer starr_01166 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:64784525-64784634 Neighboring gene pleckstrin homology domain containing, family M, member 3 Neighboring gene leucine rich repeat containing 15 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:64912785-64913085 Neighboring gene predicted gene, 51628

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC141642

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Wnt receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Wnt-protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Wnt-protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Spemann organizer formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Spemann organizer formation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in anterior/posterior axis specification, embryo IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior/posterior axis specification, embryo ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within branching involved in labyrinthine layer morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to molecule of bacterial origin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to molecule of bacterial origin ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chorionic trophoblast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic axis specification ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic camera-type eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within glandular epithelial cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intestinal epithelial cell maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in non-canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within positive regulation of JUN kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of T cell cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-1 beta production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within post-embryonic camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-embryonic camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in presynapse assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of chorionic trophoblast cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within syncytiotrophoblast cell differentiation involved in labyrinthine layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    frizzled-5
    Names
    frizzled homolog 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042659.2NP_001036124.1  frizzled-5 precursor

      See identical proteins and their annotated locations for NP_001036124.1

      Status: VALIDATED

      Source sequence(s)
      AC101915
      Consensus CDS
      CCDS15008.1
      UniProtKB/Swiss-Prot
      G5E8F0, O08975, Q8BMR2, Q8CHK9, Q9EQD0
      UniProtKB/TrEMBL
      Q149L3
      Related
      ENSMUSP00000111828.3, ENSMUST00000116133.4
      Conserved Domains (3) summary
      cd07460
      Location:29156
      CRD_FZ5; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 5 (Fz5) receptor.proteins
      cd14964
      Location:235259
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:225535
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    2. NM_022721.4NP_073558.2  frizzled-5 precursor

      See identical proteins and their annotated locations for NP_073558.2

      Status: VALIDATED

      Source sequence(s)
      AC101915
      Consensus CDS
      CCDS15008.1
      UniProtKB/Swiss-Prot
      G5E8F0, O08975, Q8BMR2, Q8CHK9, Q9EQD0
      UniProtKB/TrEMBL
      Q149L3
      Related
      ENSMUSP00000067783.6, ENSMUST00000063982.7
      Conserved Domains (3) summary
      cd07460
      Location:29156
      CRD_FZ5; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 5 (Fz5) receptor.proteins
      cd14964
      Location:235259
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:225535
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      64769717..64776907 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001033193.1: Suppressed sequence

      Description
      NM_001033193.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.