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    Srrd SRR1 domain containing [ Mus musculus (house mouse) ]

    Gene ID: 70118, updated on 9-Dec-2024

    Summary

    Official Symbol
    Srrdprovided by MGI
    Official Full Name
    SRR1 domain containingprovided by MGI
    Primary source
    MGI:MGI:1917368
    See related
    Ensembl:ENSMUSG00000029346 AllianceGenome:MGI:1917368
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Srr1; 2810002G02Rik
    Summary
    Involved in regulation of circadian rhythm and regulation of heme biosynthetic process. Located in cytoplasm. Is expressed in genitourinary system. Orthologous to human SRRD (SRR1 domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 28.0), ovary adult (RPKM 22.9) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Srrd in Genome Data Viewer
    Location:
    5 F; 5 54.69 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (112485257..112490921, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (112337391..112343040, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6366 Neighboring gene STARR-positive B cell enhancer ABC_E1685 Neighboring gene predicted gene, 46941 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:112714594-112714795 Neighboring gene STARR-positive B cell enhancer ABC_E3600 Neighboring gene protein-tyrosine sulfotransferase 2 Neighboring gene tuftelin interacting protein 11 Neighboring gene HPS4, biogenesis of lysosomal organelles complex 3 subunit 2 Neighboring gene coiled-coil domain containing 121, retrogene 3 Neighboring gene predicted gene 20636

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in rhythmic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    SRR1-like protein
    Names
    SRR1 domain-containing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359388.1NP_001346317.1  SRR1-like protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC123848
      UniProtKB/TrEMBL
      F6Q7H5
      Related
      ENSMUSP00000119870.2, ENSMUST00000146510.8
      Conserved Domains (1) summary
      cl06844
      Location:111225
      SRR1; SRR1
    2. NM_027323.2NP_081599.2  SRR1-like protein isoform 2

      See identical proteins and their annotated locations for NP_081599.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in the 3' end compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK012640, AV513732, BC030678, BY291840
      Consensus CDS
      CCDS51614.1
      UniProtKB/Swiss-Prot
      Q08AU8, Q8K2M3, Q9CSK3
      Related
      ENSMUSP00000031289.7, ENSMUST00000031289.7
      Conserved Domains (1) summary
      cl06844
      Location:111225
      SRR1; SRR1

    RNA

    1. NR_153105.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123848, BQ179086
    2. NR_153106.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC123848

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      112485257..112490921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004942557.1 RNA Sequence