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    Pitpnb phosphatidylinositol transfer protein, beta [ Mus musculus (house mouse) ]

    Gene ID: 56305, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pitpnbprovided by MGI
    Official Full Name
    phosphatidylinositol transfer protein, betaprovided by MGI
    Primary source
    MGI:MGI:1927542
    See related
    Ensembl:ENSMUSG00000050017 AllianceGenome:MGI:1927542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PI-TP-beta
    Summary
    This gene encodes a member of the phosphatidylinositol transfer protein family. The encoded protein catalyzes the transfer of phospholipids (phosphatidylinositol and phosphatidylcholine) between membranes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 26.4), bladder adult (RPKM 24.5) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pitpnb in Genome Data Viewer
    Location:
    5 F; 5 53.79 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (111478563..111536225)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (111330697..111388359)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene microRNA 701 Neighboring gene STARR-seq mESC enhancer starr_13978 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:111589073-111589226 Neighboring gene STARR-positive B cell enhancer mm9_chr5:111607344-111607645 Neighboring gene predicted gene, 35628 Neighboring gene predicted gene, 36027 Neighboring gene meningioma 1 Neighboring gene predicted gene, 42155 Neighboring gene predicted gene, 42154

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylcholine transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylcholine transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipid binding ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    enables sphingomyelin transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    phosphatidylinositol transfer protein beta isoform
    Names
    Pitp beta
    phosphotidylinositol transfer protein, beta
    ptdIns transfer protein beta
    ptdInsTP beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301643.1NP_001288572.1  phosphatidylinositol transfer protein beta isoform isoform 1

      See identical proteins and their annotated locations for NP_001288572.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC122226, BC034676, BY205337
      Consensus CDS
      CCDS80368.1
      UniProtKB/TrEMBL
      Q8JZZ5
      Related
      ENSMUSP00000142732.2, ENSMUST00000200298.2
      Conserved Domains (1) summary
      cd08888
      Location:3258
      SRPBCC_PITPNA-B_like; Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)
    2. NM_001301644.1NP_001288573.1  phosphatidylinositol transfer protein beta isoform isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR, cause translation initiation at a downstream start codon, and result in a distinct 3' coding region and UTR, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC122226, AK028235, BC034676, BY205337, CK619028
      UniProtKB/Swiss-Prot
      P53811
      UniProtKB/TrEMBL
      Q8JZZ5
      Conserved Domains (1) summary
      cl14643
      Location:1186
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    3. NM_001301666.1NP_001288595.1  phosphatidylinositol transfer protein beta isoform isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 4, which is shorter compared to isoform 1.
      Source sequence(s)
      AC122226, BC034676, BQ178694, BY205337
      UniProtKB/TrEMBL
      Q8JZZ5
      Conserved Domains (1) summary
      cd08888
      Location:3230
      SRPBCC_PITPNA-B_like; Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)
    4. NM_001359215.1NP_001346144.1  phosphatidylinositol transfer protein beta isoform isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      AC122226
      Conserved Domains (1) summary
      cd08888
      Location:3257
      SRPBCC_PITPNA-B_like; Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)
    5. NM_001359216.1NP_001346145.1  phosphatidylinositol transfer protein beta isoform isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two alternate exons and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (6) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC122226
      Conserved Domains (1) summary
      cl14643
      Location:8200
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    6. NM_001359217.1NP_001346146.1  phosphatidylinositol transfer protein beta isoform isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (7) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC122226
      Conserved Domains (1) summary
      cl14643
      Location:1185
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    7. NM_019640.5NP_062614.1  phosphatidylinositol transfer protein beta isoform isoform 2

      See identical proteins and their annotated locations for NP_062614.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AC122226, AK028235, BC034676, BY205337
      Consensus CDS
      CCDS39213.1
      UniProtKB/Swiss-Prot
      P53811
      Related
      ENSMUSP00000083835.5, ENSMUST00000086635.9
      Conserved Domains (1) summary
      cd08888
      Location:3259
      SRPBCC_PITPNA-B_like; Lipid-binding SRPBCC domain of mammalian PITPNA, -B, and related proteins (Class I PITPs)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      111478563..111536225
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)