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    MAP1 methionine aminopeptidase MAP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850945, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MAP1
    Official Full Name
    methionine aminopeptidase MAP1
    Primary source
    SGD:S000004234
    Locus tag
    YLR244C
    See related
    AllianceGenome:SGD:S000004234; FungiDB:YLR244C; VEuPathDB:YLR244C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity and metalloaminopeptidase activity. Involved in negative regulation of gene expression. Located in cytosolic ribosome. Orthologous to human METAP1 (methionyl aminopeptidase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MAP1 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (625168..626331, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene sterol homeostasis protein ARV1 Neighboring gene putative signal sequence-binding GTPase GPN3 Neighboring gene cytidine deaminase Neighboring gene palmitoyltransferase ERF2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, sequencing, deletion, and overexpression of a methionine aminopeptidase gene from Saccharomyces cerevisiae. Chang YH, et al. J Biol Chem, 1992 Apr 25. PMID 1569059
    2. Purification and characterization of a methionine aminopeptidase from Saccharomyces cerevisiae. Chang YH, et al. J Biol Chem, 1990 Nov 15. PMID 2246265
    3. Evidence that two zinc fingers in the methionine aminopeptidase from Saccharomyces cerevisiae are important for normal growth. Zuo S, et al. Mol Gen Genet, 1995 Jan 20. PMID 7862096
    4. Yeast (Saccharomyces cerevisiae) methionine aminopeptidase I: rapid purification and improved activity assay. Walker KW, et al. Biotechnol Appl Biochem, 1999 Apr. PMID 10075912
    5. Yeast methionine aminopeptidase type 1 is ribosome-associated and requires its N-terminal zinc finger domain for normal function in vivo. Vetro JA, et al. J Cell Biochem, 2002. PMID 11968008

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains.
      Title: The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains.
    2. Data show that overexpression of the enzyme Map1 negatively affects the expression of experimentally defined mRNA targets.
      Title: A screen for RNA-binding proteins in yeast indicates dual functions for many enzymes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables initiator methionyl aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosolic ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methionine aminopeptidase MAP1
    NP_013345.1
    • Methionine aminopeptidase; catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p; apo-Map1p is activated by the GTP-dependent zinc transferase Zng1p, especially during zinc starvation; interacts with Zng1p via an N-terminal Zn finger domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      625168..626331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182131.1 → NP_013345.1  TPA: methionine aminopeptidase MAP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013345.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYP2, Q01662
      UniProtKB/TrEMBL
      A7A1C7, B3RHC9, C7GQZ2, C8ZDK7, G2WJ70, N1NYG1
      Conserved Domains (1) summary
      PLN03158
      Location:23 → 379
      PLN03158; methionine aminopeptidase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01662.2

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