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    SET4 Set4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853339, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SET4
    Official Full Name
    Set4p
    Primary source
    SGD:S000003641
    Locus tag
    YJL105W
    See related
    AllianceGenome:SGD:S000003641; FungiDB:YJL105W; VEuPathDB:YJL105W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable methylated histone binding activity. Acts upstream of or within chromatin remodeling and regulation of cellular response to oxidative stress. Predicted to be part of Rpd3L-Expanded complex and Set3 complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SET4 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (225055..226737)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene pheromone-regulated protein PRM10 Neighboring gene uncharacterized protein Neighboring gene protein kinase IME2 Neighboring gene import motor complex subunit PAM16 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Adaptive local false discovery rate procedures for highly spiky data and their application RNA sequencing data of yeast SET4 deletion mutants. Ramos ML, et al. Biom J, 2021 Dec. PMID 34320248, Free PMC Article
    2. SET domains and stress: uncovering new functions for yeast Set4. Tran K, et al. Curr Genet, 2019 Jun. PMID 30523388, Free PMC Article
    3. Set4 is a chromatin-associated protein, promotes survival during oxidative stress, and regulates stress response genes in yeast. Tran K, et al. J Biol Chem, 2018 Sep 14. PMID 30082318, Free PMC Article
    4. Evolution of SET-domain protein families in the unicellular and multicellular Ascomycota fungi. Veerappan CS, et al. BMC Evol Biol, 2008 Jul 1. PMID 18593478, Free PMC Article
    5. The Set2 methyltransferase associates with Ssn6 yet Tup1-Ssn6 repression is independent of histone methylation. Tripic T, et al. Biochem Biophys Res Commun, 2006 Jan 20. PMID 16329992

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres.
      Title: Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres.
    2. integrate our new observations on the function of Set4 with known roles for other related family members, including yeast Set3, fly UpSET and mammalian proteins MLL5 and SETD5[review]
      Title: SET domains and stress: uncovering new functions for yeast Set4.
    3. This work advances our understanding of mechanisms that protect cells during oxidative stress and further defines the role of the Set3-Set4 subfamily of SET domain-containing proteins in controlling gene expression in response to adverse environmental conditions
      Title: Set4 is a chromatin-associated protein, promotes survival during oxidative stress, and regulates stress response genes in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Set4p
    NP_012430.1
    • Chromatin-associated protein involved in control of stress response; regulates response to oxidative stress; involved in control of gene repression in subtelomeric chromatin; contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      225055..226737
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181538.1 → NP_012430.1  TPA: Set4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012430.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW79, P42948
      UniProtKB/TrEMBL
      B3LQ08, C7GR09, C8ZBB0
      Conserved Domains (1) summary
      COG2940
      Location:16 → 526
      SET; SET domain-containing protein (function unknown) [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P42948.1

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