COX2 cytochrome c oxidase subunit 2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: COX2
Official Full Name: cytochrome c oxidase subunit 2
Primary source: SGD:S000007281
Locus tag: Q0250
See related: AllianceGenome:SGD:S000007281; FungiDB:Q0250; VEuPathDB:Q0250
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Saccharomyces cerevisiae S288C (strain: S288C, substrain: FY1679)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: OXI1; OXII
Summary: Contributes to cytochrome-c oxidase activity. Involved in mitochondrial electron transport, cytochrome c to oxygen. Located in mitochondrion. Part of respiratory chain complex IV. Orthologous to human MTCO2P12 (MT-CO2 pseudogene 12) and MT-CO2 (mitochondrially encoded cytochrome c oxidase II). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See COX2 in Genome Data Viewer

Sequence:: Chromosome: MT; NC_001224.1 (73758..74513)

Chromosome MT - NC_001224.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001224.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cytosol-synthesized subunit II (Cox2) precursor with the point mutation W56R is correctly processed in yeast mitochondria to rescue cytochrome oxidase.
Title: The cytosol-synthesized subunit II (Cox2) precursor with the point mutation W56R is correctly processed in yeast mitochondria to rescue cytochrome oxidase.
A single mutation in the first Cox2 transmembrane domain was identified that results in the cellular expression of a Cox2 variant with a molecular mass indicative of mitochondrial targeting sequences cleavage.
Title: A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression.
yeast prion causes newly synthesized prohibitins to aggregate in the cytosol, and therefore reduces their levels in mitochondria, which in turn reduces the stability of Cox2 and possibly of other proteins, not investigated here in detail.
Title: Yeast prion [PSI+] lowers the levels of mitochondrial prohibitins.
Yme1 probably chaperones the folding and/or assembly of Oxa1-exported Cox2 in the absence of Mrg1 or Mgr3, since respiratory growth and cytochrome c oxidase assembly in a cox18 mgr3 double-mutant strain overexpressing OXA1 is YME1 dependent
Title: Translocation and assembly of mitochondrially coded Saccharomyces cerevisiae cytochrome c oxidase subunit Cox2 by Oxa1 and Yme1 in the absence of Cox18.
These studies implicate different surfaces on Sco1 for interaction or function with Cox17 and Cox2.
Title: Mapping the functional interaction of Sco1 and Cox2 in cytochrome oxidase biogenesis.
Immunoblot analysis of yeast wild-type and Cox2p mutants revealed five cytochrome oxidase complexes or subcomplexes: a, b, c, d and f.
Title: Analysis of COX2 mutants reveals cytochrome oxidase subassemblies in yeast.
Data show that Rsm28p is a dispensable small-subunit mitochondrial ribosomal protein with a positive role in translation of several mitochondrial mRNAs, including COX2.
Title: Alteration of a novel dispensable mitochondrial ribosomal small-subunit protein, Rsm28p, allows translation of defective COX2 mRNAs.
The C-tail domain is recognized posttranslationally by a specialized translocation apparatus after the N-tail has been translocated by Oxa1.
Title: Translocation of mitochondrially synthesized Cox2 domains from the matrix to the intermembrane space.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
contributes_to cytochrome-c oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to cytochrome-c oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cytochrome-c oxidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP synthesis coupled electron transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IDA Inferred from Direct Assay more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex IV	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytochrome c oxidase subunit 2

NP_009326.1

EC 7.1.1.9

Subunit II of cytochrome c oxidase (Complex IV); Complex IV is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001224.1 Reference assembly

Range

73758..74513

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_009326.1 cytochrome c oxidase subunit 2 (mitochondrion) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009326.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

A0A0A7NYF9, P00410

UniProtKB/TrEMBL

A0A0H3WI21, G2HKF1, I6QCX2

Conserved Domains (1) summary

MTH00154
Location:24 → 249

COX2; cytochrome c oxidase subunit II; Provisional