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    COG2 Golgi transport complex subunit COG2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853017, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COG2
    Official Full Name
    Golgi transport complex subunit COG2
    Primary source
    SGD:S000003352
    Locus tag
    YGR120C
    See related
    AllianceGenome:SGD:S000003352; FungiDB:YGR120C; VEuPathDB:YGR120C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SEC35
    Summary
    Involved in Golgi vesicle transport; cytoplasm to vacuole targeting by the Cvt pathway; and pexophagy. Located in cytosol. Part of Golgi transport complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COG2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (730033..730821, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S23A Neighboring gene FG-nucleoporin NUP57 Neighboring gene tRNA-Asn Neighboring gene ammonium permease MEP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of conserved oligomeric Golgi complex subunit 2. Cavanaugh LF, et al. J Biol Chem, 2007 Aug 10. PMID 17565980
    2. A Rab requirement is not bypassed in SLY1-20 suppression. Ballew N, et al. Mol Biol Cell, 2005 Apr. PMID 15689495, Free PMC Article
    3. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Shemorry A, et al. Mol Cell, 2013 May 23. PMID 23603116, Free PMC Article
    4. Characterization of Grp1p, a novel cis-Golgi matrix protein. Kim DW. Biochem Biophys Res Commun, 2003 Mar 28. PMID 12646213
    5. Molecular organization of the COG vesicle tethering complex. Lees JA, et al. Nat Struct Mol Biol, 2010 Nov. PMID 20972446, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Cog1, a subunit of the Golgi-associated COG complex, is also shown to contain an Ac/N-degron interacts with Cog2, Cog3 and Cog4.
      Title: Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway.
    2. analysis of structure of the conserved oligomeric Golgi complex subunit
      Title: Structural analysis of conserved oligomeric Golgi complex subunit 2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi transport complex subunit COG2
    NP_011635.2
    • Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments; the components of the Golgi complex are Gog1p through Cog8p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      730033..730821 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181249.1 → NP_011635.2  TPA: Golgi transport complex subunit COG2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011635.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUQ1, P53271
      UniProtKB/TrEMBL
      A6ZUD3, B3LIA9, C7GUH4, C8Z911, G2WEK2
      Conserved Domains (1) summary
      cl19297
      Location:41 → 154
      Dor1; Dor1-like family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53271.2

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