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    AGX1 alanine--glyoxylate transaminase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850514, updated on 9-Dec-2024

    Summary

    Official Symbol
    AGX1
    Official Full Name
    alanine--glyoxylate transaminase
    Primary source
    SGD:S000001864
    Locus tag
    YFL030W
    See related
    AllianceGenome:SGD:S000001864; FungiDB:YFL030W; VEuPathDB:YFL030W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alanine-glyoxylate transaminase activity. Involved in glycine biosynthetic process, by transamination of glyoxylate. Located in cytosol and mitochondrion. Used to study primary hyperoxaluria. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See AGX1 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (76831..77988)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene protein kinase RIM15 Neighboring gene transcription factor HAC1 Neighboring gene cyclin-dependent protein kinase-activating kinase CAK1 Neighboring gene putative ATP-binding cassette family ATPase CAF16

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    alanine--glyoxylate transaminase
    NP_116623.1
    • Alanine:glyoxylate aminotransferase (AGT); catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; similar to mammalian and plant alanine:glyoxylate aminotransferases; human homolog AGXT complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      76831..77988
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179936.1NP_116623.1  TPA: alanine--glyoxylate transaminase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116623.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTK0, P43567
      UniProtKB/TrEMBL
      A7A209, B3LUI1, C7GY81, C8Z7Q3, G2WDB1, N1PA19
      Conserved Domains (1) summary
      cd06451
      Location:7378
      AGAT_like; Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), ...