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    URC2 Urc2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    URC2
    Official Full Name
    Urc2p
    Primary source
    SGD:S000002928
    Locus tag
    YDR520C
    See related
    AllianceGenome:SGD:S000002928; FungiDB:YDR520C; VEuPathDB:YDR520C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RRT4
    Summary
    Enables sequence-specific DNA binding activity. Predicted to be involved in nitrogen catabolite activation of transcription from RNA polymerase II promoter and uracil catabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See URC2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1481085..1483403, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein disulfide isomerase EUG1 Neighboring gene peptidylprolyl isomerase family protein FPR2 Neighboring gene Sps2p Neighboring gene putative serine/threonine protein kinase SPS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone acetylation and transcriptional regulation in the genome of Saccharomyces cerevisiae. Guo X, et al. Bioinformatics, 2006 Feb 15. PMID 16339282
    2. A second pathway to degrade pyrimidine nucleic acid precursors in eukaryotes. Andersen G, et al. J Mol Biol, 2008 Jul 18. PMID 18550080
    3. Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae. Hwang GW, et al. J Toxicol Sci, 2009 Oct. PMID 19652468
    4. Transcriptional activators in yeast. Titz B, et al. Nucleic Acids Res, 2006. PMID 16464826, Free PMC Article
    5. Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae. Hontz RD, et al. Genetics, 2009 May. PMID 19270272, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Its over expression confers resistance to cadmium in Saddharomyces cerevisiae.
      Title: Overexpression of Ycg1 or Ydr520c confers resistance to cadmium in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cytosine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrogen catabolite activation of transcription from RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in uracil catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Urc2p
    NP_010808.3
    • Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1481085..1483403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180828.3 → NP_010808.3  TPA: Urc2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010808.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTE1, Q04411
      UniProtKB/TrEMBL
      A6ZZA7, B3LFF0, C7GKV2, C8Z676, N1P5V7
      Conserved Domains (1) summary
      smart00066
      Location:66 → 109
      GAL4; GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04411.1

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