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    vqsM HTH-type transcriptional regulator VqsM [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882297, updated on 24-Aug-2024

    Summary

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    Gene symbol
    vqsM
    Gene description
    HTH-type transcriptional regulator VqsM
    Locus tag
    PA2227
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2448568..2449545, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular mechanisms of master regulator VqsM mediating quorum-sensing and antibiotic resistance in Pseudomonas aeruginosa. Liang H, et al. Nucleic Acids Res, 2014. PMID 25034696, Free PMC Article
    2. VqsM, a novel AraC-type global regulator of quorum-sensing signalling and virulence in Pseudomonas aeruginosa. Dong YH, et al. Mol Microbiol, 2005 Oct. PMID 16194239
    3. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    4. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article
    5. Cystic fibrosis sputum supports growth and cues key aspects of Pseudomonas aeruginosa physiology. Palmer KL, et al. J Bacteriol, 2005 Aug. PMID 16030221, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This work pinpoints the binding motif and direct in vivo targets of VqsM, and also demonstrates that VqsM plays important roles in tuning type III secretion system and antibiotic resistance.
      Title: Molecular mechanisms of master regulator VqsM mediating quorum-sensing and antibiotic resistance in Pseudomonas aeruginosa.
    2. Results demonstrate that VqsM, largely through modulation of vqsR expression, plays a vital role in regulation of QS signalling in Pseudomonas aeruginosa.
      Title: VqsM, a novel AraC-type global regulator of quorum-sensing signalling and virulence in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    HTH-type transcriptional regulator VqsM
    NP_250917.1
    • class 1: Function experimentally demonstrated in P. aeruginosa

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2448568..2449545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250917.1 HTH-type transcriptional regulator VqsM [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250917.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9I1P2
      Conserved Domains (2) summary
      COG2207
      Location:205 → 324
      AraC; AraC-type DNA-binding domain and AraC-containing proteins [Transcription]
      pfam12625
      Location:53 → 184
      Arabinose_bd; Arabinose-binding domain of AraC transcription regulator, N-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I1P2.1

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