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    ptxR HTH-type transcriptional regulator PtxR [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878030, updated on 18-Sep-2024

    Summary

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    Gene symbol
    ptxR
    Gene description
    HTH-type transcriptional regulator PtxR
    Locus tag
    PA2258
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2486355..2487293, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene paerucumarin biosynthesis protein PvcB Neighboring gene paerucumarin biosynthesis protein PvcC Neighboring gene paerucumarin biosynthesis protein PvcD Neighboring gene transcriptional regulator PtxS Neighboring gene hypothetical protein Neighboring gene 2-ketogluconate kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a Pseudomonas aeruginosa gene, ptxR, which positively regulates exotoxin A production. Hamood AN, et al. Mol Microbiol, 1996 Jul. PMID 8843437
    2. PtxR modulates the expression of QS-controlled virulence factors in the Pseudomonas aeruginosa strain PAO1. Carty NL, et al. Mol Microbiol, 2006 Aug. PMID 16803594
    3. Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR. Colmer-Hamood JA, et al. Can J Microbiol, 2006 Apr. PMID 16699585
    4. Regulation of Pseudomonas aeruginosa ptxR by Vfr. Ferrell E, et al. Microbiology (Reading), 2008 Feb. PMID 18227247
    5. Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS. Daddaoua A, et al. PLoS One, 2012. PMID 22844393, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PtxS modulates PtxR activity in response to 2-ketogluconate by complex formation in solution in the case of the P(toxA) promoter, or via the formation of a DNA loop as in the regulation of gluconate catabolic genes
      Title: Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS.
    2. This study showed within the ptxR upstream region, a 25 bp sequence to which Vfr specifically binds.
      Title: Regulation of Pseudomonas aeruginosa ptxR by Vfr.
    3. Results suggest that different segments of the ptxR upstream region play specific roles in ptxR expression and their deletion caused variations in the level as well as the pattern of ptxR expression.
      Title: Transcriptional analysis of the Pseudomonas aeruginosa toxA regulatory gene ptxR.
    4. PtxR negatively regulates the expression of the virulence factors, such as rhamnolipid and pyocyanin genes
      Title: PtxR modulates the expression of QS-controlled virulence factors in the Pseudomonas aeruginosa strain PAO1.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables NAD+-protein poly-ADP-ribosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of secondary metabolite biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    HTH-type transcriptional regulator PtxR
    NP_250948.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2486355..2487293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250948.1 HTH-type transcriptional regulator PtxR [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250948.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      O30374
      Conserved Domains (2) summary
      cd08422
      Location:101 → 297
      PBP2_CrgA_like; The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain
      pfam00126
      Location:13 → 56
      HTH_1; Bacterial regulatory helix-turn-helix protein, lysR family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P72131.1

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