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    RFC5 replication factor C subunit 5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852383, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RFC5
    Official Full Name
    replication factor C subunit 5
    Primary source
    SGD:S000000291
    Locus tag
    YBR087W
    See related
    AllianceGenome:SGD:S000000291; FungiDB:YBR087W; VEuPathDB:YBR087W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to DNA clamp loader activity. Involved in leading strand elongation and sister chromatid cohesion. Part of chromosome. Orthologous to human RFC3 (replication factor C subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RFC5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (423765..424829)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ist2p Neighboring gene proliferating cell nuclear antigen Neighboring gene uncharacterized protein Neighboring gene high-mobility group nucleosome-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of a 70 kb region on the right arm of yeast chromosome II. Mannhaupt G, et al. Yeast, 1994 Oct. PMID 7900426
    2. Identification of the fifth subunit of Saccharomyces cerevisiae replication factor C. Gary SL, et al. Nucleic Acids Res, 1995 Dec 25. PMID 8559655, Free PMC Article
    3. Allele-specific interactions between the yeast RFC1 and RFC5 genes suggest a basis for RFC subunit-subunit interactions. Beckwith W, et al. Mol Gen Genet, 2000 Nov. PMID 11129041
    4. Rfc5, a small subunit of replication factor C complex, couples DNA replication and mitosis in budding yeast. Sugimoto K, et al. Proc Natl Acad Sci U S A, 1996 Jul 9. PMID 8692942, Free PMC Article
    5. The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1). Lengronne A, et al. Mol Cell, 2002 May. PMID 12049742

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A novel and critical role for the small RFC subunit Rfc5p promotes anti-establishment activities.
      Title: Rfc5p regulates alternate RFC complex functions in sister chromatid pairing reactions in budding yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA clamp loader activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to DNA clamp loader activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA clamp unloading IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA strand elongation involved in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in leading strand elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ctf18 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ctf18 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of DNA replication factor C complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor C complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of DNA replication factor C complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of Elg1 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Elg1 RFC-like complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Elg1 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of Rad17 RFC-like complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Rad17 RFC-like complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Rad17 RFC-like complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    replication factor C subunit 5
    NP_009644.3
    • Subunit of heteropentameric Replication factor C (RF-C); RF-C is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      423765..424829
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178435.3 → NP_009644.3  TPA: replication factor C subunit 5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009644.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ88, P38251
      UniProtKB/TrEMBL
      A6ZL35, B3LN63, B5VE52, C7GJS2, D3UEI2, G2W995, N1P9F3
      Conserved Domains (2) summary
      COG0470
      Location:161 → 351
      HolB; DNA polymerase III, delta prime subunit [Replication, recombination and repair]
      PRK12402
      Location:3 → 243
      PRK12402; replication factor C small subunit 2; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38251.1

    Gene LinkOut

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