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    ampR transcriptional regulator AmpR [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 877983, updated on 24-Aug-2024

    Summary

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    Gene symbol
    ampR
    Gene description
    transcriptional regulator AmpR
    Locus tag
    PA4109
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (4592990..4593880, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene cyclic di-GMP phosphodiesterase Neighboring gene hypothetical protein Neighboring gene beta-lactamase Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deep sequencing analyses expands the Pseudomonas aeruginosa AmpR regulon to include small RNA-mediated regulation of iron acquisition, heat shock and oxidative stress response. Balasubramanian D, et al. Nucleic Acids Res, 2014 Jan. PMID 24157832, Free PMC Article
    2. Co-regulation of {beta}-lactam resistance, alginate production and quorum sensing in Pseudomonas aeruginosa. Balasubramanian D, et al. J Med Microbiol, 2011 Feb. PMID 20965918, Free PMC Article
    3. The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes. Balasubramanian D, et al. PLoS One, 2012. PMID 22479525, Free PMC Article
    4. LTQ-XL mass spectrometry proteome analysis expands the Pseudomonas aeruginosa AmpR regulon to include cyclic di-GMP phosphodiesterases and phosphoproteins, and identifies novel open reading frames. Kumari H, et al. J Proteomics, 2014 Jan 16. PMID 24291602, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The AmpR proteome data not only confirmed the role of AmpR in virulence and resistance to multiple antibiotics, but also expanded the perimeter of AmpR regulon.
      Title: LTQ-XL mass spectrometry proteome analysis expands the Pseudomonas aeruginosa AmpR regulon to include cyclic di-GMP phosphodiesterases and phosphoproteins, and identifies novel open reading frames.
    2. Authors assign a role for AmpR in previously unidentified critical cellular processes such as iron uptake, oxidative stress and heat shock.
      Title: Deep sequencing analyses expands the Pseudomonas aeruginosa AmpR regulon to include small RNA-mediated regulation of iron acquisition, heat shock and oxidative stress response.
    3. The regulatory repertoire of Pseudomonas aeruginosa AmpC ss-lactamase regulator AmpR includes virulence genes
      Title: The regulatory repertoire of Pseudomonas aeruginosa AmpC ß-lactamase regulator AmpR includes virulence genes.
    4. This study is indicative of the existence of a co-regulatory network between beta-lactam resistance, alginate production, quorum sensing and virulence factor production, with AmpR playing a central role.
      Title: Co-regulation of {beta}-lactam resistance, alginate production and quorum sensing in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of single-species biofilm formation on inanimate substrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of secondary metabolite biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional regulator AmpR
    NP_252798.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      4592990..4593880 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252798.1 transcriptional regulator AmpR [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252798.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A367M1X4
      Conserved Domains (2) summary
      cd08484
      Location:95 → 285
      PBP2_LTTR_beta_lactamase; The C-terminal substrate-domain of LysR-type transcriptional regulators for beta-lactamase genes, contains the type 2 periplasmic binding fold
      pfam00126
      Location:8 → 67
      HTH_1; Bacterial regulatory helix-turn-helix protein, lysR family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24734.3

    Gene LinkOut

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    Research Materials