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    ORC4 origin recognition complex subunit 4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856291, updated on 9-Dec-2024

    Summary

    Official Symbol
    ORC4
    Official Full Name
    origin recognition complex subunit 4
    Primary source
    SGD:S000006366
    Locus tag
    YPR162C
    See related
    AllianceGenome:SGD:S000006366; FungiDB:YPR162C; VEuPathDB:YPR162C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA replication origin binding activity. Involved in DNA replication initiation; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; and silent mating-type cassette heterochromatin formation. Part of DNA replication preinitiation complex; nuclear origin of replication recognition complex; and nuclear pre-replicative complex. Used to study Meier-Gorlin syndrome. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 2. Orthologous to human ORC4 (origin recognition complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See ORC4 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (866715..868304, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene glycogen phosphorylase Neighboring gene cyclin-dependent serine/threonine protein kinase SGV1 Neighboring gene Tif3p Neighboring gene Mms1p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of DNA replication preinitiation complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear origin of replication recognition complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear origin of replication recognition complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    part_of nuclear pre-replicative complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of origin recognition complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    origin recognition complex subunit 4
    NP_015488.1
    • Subunit of the origin recognition complex (ORC); ORC directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; ORC4 has a paralog, RIF2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      866715..868304 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184259.1NP_015488.1  TPA: origin recognition complex subunit 4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015488.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4G3, P54791
      UniProtKB/TrEMBL
      A6ZX38, B3LKC3, C7GP45, C8ZJI8, N1NWJ7
      Conserved Domains (2) summary
      COG1474
      Location:95276
      CDC6; Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]
      pfam14629
      Location:286517
      ORC4_C; Origin recognition complex (ORC) subunit 4 C-terminus