U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Chek1 checkpoint kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 12649, updated on 13-Jan-2025

    Summary

    Official Symbol
    Chek1provided by MGI
    Official Full Name
    checkpoint kinase 1provided by MGI
    Primary source
    MGI:MGI:1202065
    See related
    Ensembl:ENSMUSG00000032113 AllianceGenome:MGI:1202065
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Chk1; rad27
    Summary
    Enables histone H3T11 kinase activity. Involved in negative regulation of gene expression, epigenetic. Acts upstream of or within several processes, including DNA damage checkpoint signaling; G2/M transition of mitotic cell cycle; and inner cell mass cell proliferation. Located in chromatin; nucleus; and replication fork. Is expressed in several structures, including adrenal medulla; brain; early conceptus; gonad; and gut. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human CHEK1 (checkpoint kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in CNS E11.5 (RPKM 8.0), liver E14 (RPKM 5.6) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Chek1 in Genome Data Viewer
    Location:
    9 A4; 9 20.67 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (36619935..36637897, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (36708482..36726658, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700027I24 gene Neighboring gene acrosomal vesicle protein 1 Neighboring gene STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E709 Neighboring gene predicted gene, 26787 Neighboring gene etoposide induced 2.4 mRNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (7)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 31
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T11 kinase activity PubMed 
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    enables protein kinase activity PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 31
    Items 1 - 25 of 42
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage checkpoint signaling PubMed 
    acts_upstream_of_or_within DNA damage checkpoint signaling PubMed 
    involved_in DNA damage checkpoint signaling  
    acts_upstream_of_or_within DNA damage response PubMed 
    involved_in DNA damage response PubMed 
    involved_in DNA damage response  
    acts_upstream_of_or_within DNA repair PubMed 
    involved_in DNA repair  
    acts_upstream_of_or_within G2/M transition of mitotic cell cycle PubMed 
    involved_in apoptotic process  
    acts_upstream_of_or_within apoptotic process involved in development PubMed 
    involved_in cellular response to caffeine  
    involved_in cellular response to mechanical stimulus  
    involved_in chromatin remodeling PubMed 
    acts_upstream_of_or_within inner cell mass cell proliferation PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling  
    involved_in mitotic G2 DNA damage checkpoint signaling  
    involved_in mitotic G2 DNA damage checkpoint signaling  
    involved_in mitotic G2/M transition checkpoint  
    involved_in mitotic G2/M transition checkpoint  
    acts_upstream_of_or_within mitotic cell cycle checkpoint signaling PubMed 
    involved_in negative regulation of DNA biosynthetic process  
    involved_in negative regulation of DNA biosynthetic process  
    involved_in negative regulation of G2/M transition of mitotic cell cycle  
    involved_in negative regulation of gene expression, epigenetic PubMed 
    involved_in negative regulation of mitotic nuclear division  
    involved_in negative regulation of mitotic nuclear division  
    acts_upstream_of_or_within nucleus organization PubMed 
    involved_in peptidyl-threonine phosphorylation  
    involved_in peptidyl-threonine phosphorylation  
    involved_in positive regulation of cell cycle  
    involved_in positive regulation of cell cycle  
    acts_upstream_of_or_within protein phosphorylation PubMed 
    involved_in protein phosphorylation  
    acts_upstream_of_or_within regulation of cell population proliferation PubMed 
    involved_in regulation of double-strand break repair via homologous recombination  
    involved_in regulation of double-strand break repair via homologous recombination  
    acts_upstream_of_or_within regulation of gene expression PubMed 
    involved_in regulation of mitotic centrosome separation  
    involved_in regulation of mitotic centrosome separation  
    involved_in signal transduction in response to DNA damage  
    involved_in signal transduction in response to DNA damage  
    Items 1 - 25 of 42
    Component Evidence Code Pubs
    located_in centrosome  
    located_in centrosome  
    located_in chromatin PubMed 
    located_in chromosome, telomeric region  
    colocalizes_with chromosome, telomeric region  
    located_in condensed nuclear chromosome  
    located_in condensed nuclear chromosome  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus  
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in replication fork PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein kinase Chk1
    Names
    CHK1 checkpoint homolog
    checkpoint kinase 1 homolog
    rad27 homolog
    NP_001397134.1
    NP_001397135.1
    NP_001397136.1
    NP_031717.2
    XP_017168606.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410205.1NP_001397134.1  serine/threonine-protein kinase Chk1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC155921
    2. NM_001410206.1NP_001397135.1  serine/threonine-protein kinase Chk1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC155921
    3. NM_001410207.1NP_001397136.1  serine/threonine-protein kinase Chk1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC155921
      UniProtKB/Swiss-Prot
      O35280, O54925, Q8CI40, Q9D0N2
      UniProtKB/TrEMBL
      Q497T8
    4. NM_007691.6NP_031717.2  serine/threonine-protein kinase Chk1 isoform 1

      See identical proteins and their annotated locations for NP_031717.2

      Status: VALIDATED

      Source sequence(s)
      AC155921
      Consensus CDS
      CCDS22972.1
      UniProtKB/Swiss-Prot
      O35280, O54925, Q8CI40, Q9D0N2
      UniProtKB/TrEMBL
      Q497T8
      Related
      ENSMUSP00000034625.6, ENSMUST00000034625.12
      Conserved Domains (1) summary
      cd14069
      Location:7265
      STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      36619935..36637897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313117.3XP_017168606.1  serine/threonine-protein kinase Chk1 isoform X1

      Conserved Domains (1) summary
      cl21453
      Location:1164
      PKc_like; Protein Kinases, catalytic domain
    External link. Please review our privacy policy.