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    Wasf3 WASP family, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 245880, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wasf3provided by MGI
    Official Full Name
    WASP family, member 3provided by MGI
    Primary source
    MGI:MGI:2658986
    See related
    Ensembl:ENSMUSG00000029636 AllianceGenome:MGI:2658986
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scar3; Wave3
    Summary
    Predicted to enable Arp2/3 complex binding activity and protein kinase A regulatory subunit binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within lamellipodium assembly; oligodendrocyte development; and positive regulation of myelination. Located in glial cell projection and lamellipodium. Is active in glutamatergic synapse and postsynapse. Is expressed in adrenal gland; cap mesenchyme; nervous system; and neural retina. Orthologous to human WASF3 (WASP family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 17.1), frontal lobe adult (RPKM 16.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Wasf3 in Genome Data Viewer
    Location:
    5 G3; 5 85.23 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146317411..146410425)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146385006..146473615)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52832 Neighboring gene predicted gene, 38747 Neighboring gene STARR-seq mESC enhancer starr_14840 Neighboring gene STARR-seq mESC enhancer starr_14845 Neighboring gene predicted gene 6408 Neighboring gene predicted gene 6370

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer. Kansakar U, et al. Sci Rep, 2021 Feb 16. PMID 33594155, Free PMC Article
    2. PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation. Corral-Serrano JC, et al. Proc Natl Acad Sci U S A, 2020 May 5. PMID 32312818, Free PMC Article
    3. Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer. Qin H, et al. Am J Pathol, 2019 Dec. PMID 31542393
    4. WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma. Sossey-Alaoui K, et al. Oncogene, 2002 Aug 29. PMID 12185600
    5. Characterization of the WAVE1 knock-out mouse: implications for CNS development. Dahl JP, et al. J Neurosci, 2003 Apr 15. PMID 12716942, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.
      Title: Phosphorylation of the proline-rich domain of WAVE3 drives its oncogenic activity in breast cancer.
    2. our work suggests that PCARE is an actin-associated protein that interacts with WASF3 to regulate the actin-driven expansion of the ciliary membrane at the initiation of new outer segment disk formation.
      Title: PCARE and WASF3 regulate ciliary F-actin assembly that is required for the initiation of photoreceptor outer segment disk formation.
    3. Elevated WASF3 Expression Promotes Metastasis in Breast Cancer.
      Title: Wasf3 Deficiency Reveals Involvement in Metastasis in a Mouse Model of Breast Cancer.
    4. p63alpha protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion
      Title: p63α protein up-regulates heat shock protein 70 expression via E2F1 transcription factor 1, promoting Wasf3/Wave3/MMP9 signaling and bladder cancer invasion.
    5. WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization.
      Title: WAVE3, an actin-polymerization gene, is truncated and inactivated as a result of a constitutional t(1;13)(q21;q12) chromosome translocation in a patient with ganglioneuroblastoma.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Arp2/3 complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase A regulatory subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modification of postsynaptic actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modification of postsynaptic actin cytoskeleton IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of myelination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of myelination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in glial cell projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    actin-binding protein WASF3
    Names
    WAS protein family, member 3
    WASP family protein member 3
    protein WAVE-3
    wiskott-Aldrich syndrome protein family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418239.1 → NP_001405168.1  actin-binding protein WASF3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC093356, AC115019
      UniProtKB/Swiss-Prot
      Q8VHI6
      UniProtKB/TrEMBL
      Q3V386

    2. NM_001418240.1 → NP_001405169.1  actin-binding protein WASF3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC093356, AC115019
      UniProtKB/Swiss-Prot
      Q8VHI6
      UniProtKB/TrEMBL
      Q3V386

    3. NM_001418241.1 → NP_001405170.1  actin-binding protein WASF3 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC093356, AC115019
      UniProtKB/Swiss-Prot
      Q8VHI6
      UniProtKB/TrEMBL
      Q3V386

    4. NM_001418242.1 → NP_001405171.1  actin-binding protein WASF3 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC093356, AC115019
      UniProtKB/TrEMBL
      Q3V386

    5. NM_145155.4 → NP_660137.1  actin-binding protein WASF3 isoform a

      See identical proteins and their annotated locations for NP_660137.1

      Status: VALIDATED

      Source sequence(s)
      AC093356, AC115019
      Consensus CDS
      CCDS19870.1
      UniProtKB/Swiss-Prot
      Q8VHI6
      UniProtKB/TrEMBL
      Q3V386
      Related
      ENSMUSP00000016143.8, ENSMUST00000016143.9
      Conserved Domains (1) summary
      smart00246
      Location:439 → 456
      WH2; Wiskott Aldrich syndrome homology region 2

    RNA

    1. NR_184697.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC093356, AC115019

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      146317411..146410425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504833.5 → XP_006504896.1  actin-binding protein WASF3 isoform X1

      See identical proteins and their annotated locations for XP_006504896.1

      UniProtKB/Swiss-Prot
      Q8VHI6
      UniProtKB/TrEMBL
      Q3V386
      Conserved Domains (1) summary
      smart00246
      Location:439 → 456
      WH2; Wiskott Aldrich syndrome homology region 2

    2. XM_030254506.2 → XP_030110366.1  actin-binding protein WASF3 isoform X3

      Conserved Domains (1) summary
      smart00246
      Location:227 → 244
      WH2; Wiskott Aldrich syndrome homology region 2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VHI6.1 GenPept UniProtKB/Swiss-Prot:Q8VHI6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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