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    Lipm lipase, family member M [ Mus musculus (house mouse) ]

    Gene ID: 78753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lipmprovided by MGI
    Official Full Name
    lipase, family member Mprovided by MGI
    Primary source
    MGI:MGI:1926003
    See related
    Ensembl:ENSMUSG00000056078 AllianceGenome:MGI:1926003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lipl3; 4632427C23Rik
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Predicted to be involved in lipid catabolic process. Predicted to be located in extracellular region. Is expressed in anterior naris and external naris. Orthologous to human LIPM (lipase family member M). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 1.4), stomach adult (RPKM 0.3) and 2 other tissues See more
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    Genomic context

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    See Lipm in Genome Data Viewer
    Location:
    19 C1; 19 29.32 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34078343..34100087)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34100943..34122687)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31300 Neighboring gene lipase, family member N Neighboring gene STARR-seq mESC enhancer starr_45988 Neighboring gene STARR-seq mESC enhancer starr_45989 Neighboring gene ankyrin repeat domain 22 Neighboring gene STARR-seq mESC enhancer starr_45990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:34255778-34255996 Neighboring gene STARR-positive B cell enhancer ABC_E5696 Neighboring gene STAM binding protein like 1 Neighboring gene STARR-seq mESC enhancer starr_45992 Neighboring gene actin alpha 2, smooth muscle, aorta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipase member M
    Names
    lipase-like abhydrolase domain-containing protein 3
    lipase-like, ab-hydrolase domain containing 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023903.1 → NP_076392.1  lipase member M precursor

      See identical proteins and their annotated locations for NP_076392.1

      Status: VALIDATED

      Source sequence(s)
      AK037091, AK085719
      Consensus CDS
      CCDS50419.1
      UniProtKB/Swiss-Prot
      Q8BJ28, Q8K2A6
      Related
      ENSMUSP00000025685.7, ENSMUST00000025685.8
      Conserved Domains (1) summary
      PLN02872
      Location:50 → 408
      PLN02872; triacylglycerol lipase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      34078343..34100087
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527466.4 → XP_006527529.1  lipase member M isoform X1

      See identical proteins and their annotated locations for XP_006527529.1

      UniProtKB/Swiss-Prot
      Q8BJ28, Q8K2A6
      Conserved Domains (1) summary
      PLN02872
      Location:50 → 408
      PLN02872; triacylglycerol lipase

    2. XM_006527467.4 → XP_006527530.1  lipase member M isoform X3

      Conserved Domains (1) summary
      PLN02872
      Location:1 → 218
      PLN02872; triacylglycerol lipase

    3. XM_017318314.2 → XP_017173803.1  lipase member M isoform X2

      Conserved Domains (1) summary
      PLN02872
      Location:27 → 237
      PLN02872; triacylglycerol lipase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K2A6.1 GenPept UniProtKB/Swiss-Prot:Q8K2A6

    Gene LinkOut

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