Polr1C RNA polymerase I and III subunit C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Polr1Cprovided by FlyBase
Official Full Name: RNA polymerase I and III subunit Cprovided by FlyBase
Primary source: FLYBASE:FBgn0031657
Locus tag: Dmel_CG3756
See related: AllianceGenome:FB:FBgn0031657
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AC40; CG3756; Dmel\CG3756; POLR1C; RPC40
Summary: Predicted to enable protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in tRNA transcription by RNA polymerase III and transcription by RNA polymerase I. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Orthologous to human POLR1C (RNA polymerase I and III subunit C). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4969004..4970216)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4969004..4970216)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
contributes_to RNA polymerase I activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase I activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase I activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase III activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase III activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in tRNA transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase I	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of RNA polymerase I complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase I complex	ISS Inferred from Sequence or Structural Similarity more info
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	ISS Inferred from Sequence or Structural Similarity more info

NP_608885.1

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The following sections contain reference sequences that belong to a specific genome build. Explain