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    GLO4 hydroxyacylglutathione hydrolase GLO4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854205, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GLO4
    Official Full Name
    hydroxyacylglutathione hydrolase GLO4
    Primary source
    SGD:S000005566
    Locus tag
    YOR040W
    See related
    AllianceGenome:SGD:S000005566; FungiDB:YOR040W; VEuPathDB:YOR040W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables hydroxyacylglutathione hydrolase activity. Involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in mitochondrial matrix. Human ortholog(s) of this gene implicated in paroxysmal nonkinesigenic dyskinesia 1. Orthologous to several human genes including HAGH (hydroxyacylglutathione hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GLO4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (407064..407921)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Hir2p Neighboring gene casein kinase 2 regulatory subunit CKB2 Neighboring gene ncRNA Neighboring gene ubiquitin-binding protein CUE5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterologous expression, purification, and kinetic comparison of the cytoplasmic and mitochondrial glyoxalase II enzymes, Glo2p and Glo4p, from Saccharomyces cerevisiae. Bito A, et al. Protein Expr Purif, 1999 Dec. PMID 10600466
    2. Identification and phenotypic analysis of two glyoxalase II encoding genes from Saccharomyces cerevisiae, GLO2 and GLO4, and intracellular localization of the corresponding proteins. Bito A, et al. J Biol Chem, 1997 Aug 22. PMID 9261170
    3. Assessment of chronological lifespan dependent molecular damages in yeast lacking mitochondrial antioxidant genes. Demir AB, et al. Biochem Biophys Res Commun, 2010 Sep 10. PMID 20707985
    4. Recurrent background mutations in WHI2 impair proteostasis and degradation of misfolded cytosolic proteins in Saccharomyces cerevisiae. Comyn SA, et al. Sci Rep, 2017 Jun 23. PMID 28646136, Free PMC Article
    5. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Willingham S, et al. Science, 2003 Dec 5. PMID 14657499

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxyacylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacylglutathione hydrolase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables hydroxyacylglutathione hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyacylglutathione hydrolase GLO4
    NP_014683.1
    • Mitochondrial glyoxalase II; catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate; GLO4 has a paralog, GLO2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      407064..407921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183459.1 → NP_014683.1  TPA: hydroxyacylglutathione hydrolase GLO4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014683.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2A7, Q12320
      UniProtKB/TrEMBL
      A6ZNP6, B3LJ93, B5VRU1, C7GLG9, C8ZI02, G2WMS2, N1NVR2
      Conserved Domains (2) summary
      cd07723
      Location:18 → 198
      hydroxyacylglutathione_hydrolase_MBL-fold; hydroxyacylglutathione hydrolase, MBL-fold metallo-hydrolase domain
      pfam16123
      Location:199 → 283
      HAGH_C; Hydroxyacylglutathione hydrolase C-terminus
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12320.1

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