NORAD non-coding RNA activated by DNA damage [Homo sapiens (human)] - Gene

Summary

Official Symbol: NORADprovided by HGNC
Official Full Name: non-coding RNA activated by DNA damageprovided by HGNC
Primary source: HGNC:HGNC:44311
See related: Ensembl:ENSG00000260032 MIM:617037; AllianceGenome:HGNC:44311
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LINC00657
Summary: Predicted to enable protein sequestering activity. Predicted to be involved in several processes, including determination of adult lifespan; hair follicle development; and skeletal muscle fiber development. Predicted to be active in cytoplasm. Biomarker of lung non-small cell carcinoma. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 20q11.23

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	20	NC_000020.11 (36045618..36050960, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	20	NC_060944.1 (37766598..37771940, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	20	NC_000020.10 (34633540..34638882, complement)

Chromosome 20 - NC_000020.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elevated circulating LncRNA NORAD fosters endothelial cell growth and averts ferroptosis by modulating the miR-106a/CCND1 axis in CAD patients.
Title: Elevated circulating LncRNA NORAD fosters endothelial cell growth and averts ferroptosis by modulating the miR-106a/CCND1 axis in CAD patients.
Long non-coding RNA NORAD regulates megakaryocyte differentiation and proplatelet formation via the DUSP6/ERK signaling pathway.
Title: Long non-coding RNA NORAD regulates megakaryocyte differentiation and proplatelet formation via the DUSP6/ERK signaling pathway.
Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis.
Title: Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis.
Clinical significance of long non-coding RNA NORAD in rheumatoid arthritis.
Title: Clinical significance of long non-coding RNA NORAD in rheumatoid arthritis.
"Salivary LINC00657 and miRNA-106a as diagnostic biomarkers for oral squamous cell carcinoma, an observational diagnostic study".
Title: "Salivary LINC00657 and miRNA-106a as diagnostic biomarkers for oral squamous cell carcinoma, an observational diagnostic study".
LncRNA NORAD defects deteriorate the formation of age-related macular degeneration.
Title: LncRNA NORAD defects deteriorate the formation of age-related macular degeneration.
Expression and clinical significance of lncRNA NORAD in patients with gestational hypertension.
Title: Expression and clinical significance of lncRNA NORAD in patients with gestational hypertension.
m6A Modification Mediates Exosomal LINC00657 to Trigger Breast Cancer Progression Via Inducing Macrophage M2 Polarization.
Title: m6A Modification Mediates Exosomal LINC00657 to Trigger Breast Cancer Progression Via Inducing Macrophage M2 Polarization.
lncRNA NORAD, soluble ICAM1 and their correlations may be related to the regulation of the tumor immune microenvironment in laryngeal squamous cell carcinoma (LSCC).
Title: lncRNA NORAD, soluble ICAM1 and their correlations may be related to the regulation of the tumor immune microenvironment in laryngeal squamous cell carcinoma (LSCC).
Upregulated lncRNA NORAD can diagnose acute cerebral ischemic stroke patients and predict poor prognosis.
Title: Upregulated lncRNA NORAD can diagnose acute cerebral ischemic stroke patients and predict poor prognosis.

Submit: New GeneRIF Correction See all GeneRIFs (89)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

long intergenic non-protein coding RNA 657

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein sequestering activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of mRNA stability	TAS Traceable Author Statement more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.