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    Psa Puromycin sensitive aminopeptidase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38175, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Psaprovided by FlyBase
    Official Full Name
    Puromycin sensitive aminopeptidaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261243
    Locus tag
    Dmel_CG1009
    See related
    AllianceGenome:FB:FBgn0261243
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1009; Dmel\CG1009; dPsa; dPSA; l(3)06226; PSA
    Summary
    Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytosol; extracellular space; and membrane. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; epithelium; ganglia; and male germline cell. Orthologous to several human genes including NPEPPS (aminopeptidase puromycin sensitive). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Psa in Genome Data Viewer
    Location:
    62A3-62A3; 3-0.5 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1502843..1523380)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1502843..1523380)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45812 Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU2-48 Neighboring gene half pint Neighboring gene cueball Neighboring gene Increased minichromosome loss 1 Neighboring gene Ionotropic receptor 62a Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. Menzies FM, et al. Hum Mol Genet, 2010 Dec 1. PMID 20829225, Free PMC Article
    2. Suppression of Aβ toxicity by puromycin-sensitive aminopeptidase is independent of its proteolytic activity. Kruppa AJ, et al. Biochim Biophys Acta, 2013 Dec. PMID 23911349, Free PMC Article
    3. A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. Karsten SL, et al. Neuron, 2006 Sep 7. PMID 16950154
    4. Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet in Drosophila. Hoedjes KM, et al. Evol Lett, 2019 Dec. PMID 31867121, Free PMC Article
    5. A modifier screen in the eye reveals control genes for Krüppel activity in the Drosophila embryo. Carrera P, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724781, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 1506054-1513593 mobile_element_type = transposon:17.6{}908

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aminopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    puromycin sensitive aminopeptidase
    Names
    CG1009-PA
    CG1009-PB
    CG1009-PC
    CG1009-PD
    CG1009-PE
    CG1009-PF
    CG1009-PH
    CG1009-PI
    Psa-PA
    Psa-PB
    Psa-PC
    Psa-PD
    Psa-PE
    Psa-PF
    Psa-PH
    Psa-PI
    lethal (3) 06226
    puromycin-sensitive aminopeptidase
    puromycin-sensitive-aminopeptidase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      1502843..1523380
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167886.1 → NP_728617.1  puromycin sensitive aminopeptidase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728617.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ1, Q9W0E4
      Related
      FBpp0072581, FBtr0072697
      Conserved Domains (3) summary
      cd09601
      Location:18 → 458
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:9 → 395
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:533 → 843
      ERAP1_C; ERAP1-like C-terminal domain

    2. NM_139360.3 → NP_647617.2  puromycin sensitive aminopeptidase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647617.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ1, Q9W0E4
      Related
      FBpp0072582
      Conserved Domains (3) summary
      cd09601
      Location:18 → 458
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:9 → 395
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:533 → 843
      ERAP1_C; ERAP1-like C-terminal domain

    3. NM_167885.2 → NP_728616.1  puromycin sensitive aminopeptidase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728616.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ1, Q9W0E4
      Related
      FBpp0072584
      Conserved Domains (3) summary
      cd09601
      Location:18 → 458
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:9 → 395
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:533 → 843
      ERAP1_C; ERAP1-like C-terminal domain

    4. NM_167883.2 → NP_728614.1  puromycin sensitive aminopeptidase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728614.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH92, Q8IRH1
      Related
      FBpp0072583
      Conserved Domains (3) summary
      cd09601
      Location:227 → 667
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:218 → 604
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:742 → 1052
      ERAP1_C; ERAP1-like C-terminal domain

    5. NM_167884.2 → NP_728615.1  puromycin sensitive aminopeptidase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728615.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E8NH92, Q8IRH0
      Related
      FBpp0072585
      Conserved Domains (3) summary
      cd09601
      Location:205 → 645
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:196 → 582
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:720 → 1030
      ERAP1_C; ERAP1-like C-terminal domain

    6. NM_001274329.1 → NP_001261258.1  puromycin sensitive aminopeptidase, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261258.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ1, Q9W0E4
      Conserved Domains (3) summary
      cd09601
      Location:18 → 458
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:9 → 395
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:533 → 843
      ERAP1_C; ERAP1-like C-terminal domain

    7. NM_001259617.2 → NP_001246546.1  puromycin sensitive aminopeptidase, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246546.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ1, Q9W0E4
      Conserved Domains (3) summary
      cd09601
      Location:18 → 458
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:9 → 395
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:533 → 843
      ERAP1_C; ERAP1-like C-terminal domain

    8. NM_167887.2 → NP_728618.1  puromycin sensitive aminopeptidase, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728618.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VUZ1, Q9W0E4
      Related
      FBpp0072586
      Conserved Domains (3) summary
      cd09601
      Location:18 → 458
      M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
      pfam01433
      Location:9 → 395
      Peptidase_M1; Peptidase family M1
      pfam11838
      Location:533 → 843
      ERAP1_C; ERAP1-like C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IRH0 Q8IRH0
    Q8IRH1 Q8IRH1
    Q9GPG3 Q9GPG3
    Q9W0E4 Q9W0E4

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