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    RPA1 Replication protein A1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40972, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RPA1provided by FlyBase
    Official Full Name
    Replication protein A1provided by FlyBase
    Primary source
    FLYBASE:FBgn0010173
    Locus tag
    Dmel_CG9633
    See related
    AllianceGenome:FB:FBgn0010173
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG9633; D-RPA70; D-SSB; Dmel\CG9633; DmRPA; dmrpa1; dRP-A; DRP-A; i164; RP-A; RPA; RPA 70; RPA 70 kDa; Rpa-70; RpA-70; RpA1; RpA70; RPA70; Ssb-70
    Summary
    Enables single-stranded DNA binding activity. Involved in DNA-templated DNA replication. Located in nucleus. Part of DNA replication factor A complex. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; ganglia; gut section; and head epidermis primordium. Orthologous to human RPA1 (replication protein A1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RPA1 in Genome Data Viewer
    Location:
    84F6-84F6; 3-48 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8262120..8264451, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4087842..4090173, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mind the gap Neighboring gene pseudo Neighboring gene Minichromosome maintenance 2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification and characterisation of a DNA helicase, dheI I, from Drosophila melanogaster embryos. Thömmes P, et al. Nucleic Acids Res, 1995 Nov 11. PMID 7501468, Free PMC Article
    2. Phosphorylation and localization of replication protein A during oogenesis and early embryogenesis of Drosophila melanogaster. Mitsis PG. Dev Biol, 1995 Aug. PMID 7649375
    3. A second hybrid-binding domain modulates the activity of Drosophila ribonuclease H1. González de Cózar JM, et al. J Biochem, 2020 Nov 1. PMID 32589740, Free PMC Article
    4. A new DNA polymerase species from Drosophila melanogaster: a probable mus308 gene product. Oshige M, et al. Mutat Res, 1999 Apr 9. PMID 10343651
    5. Asymmetric histone inheritance via strand-specific incorporation and biased replication fork movement. Wooten M, et al. Nat Struct Mol Biol, 2019 Aug. PMID 31358945, Free PMC Article

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. loss-of-function alleles indicate that RPA is required to prevent neuroepithelial cells from differentiating into medulla neuroblasts
      Title: Replication protein a links cell cycle progression and the onset of neurogenesis in Drosophila optic lobe development.
    2. Data show that the basic cleft of the RPA70 N-terminal OB-fold domain binds multiple checkpoint proteins, including RAD9, to promote ATR signaling.
      Title: The basic cleft of RPA70N binds multiple checkpoint proteins, including RAD9, to regulate ATR signaling.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in DNA unwinding involved in DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA replication factor A complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    replication protein A1
    Names
    CG9633-PA
    RPA1-PA
    drosophila replication protein A
    replication protein A 70
    single stranded-binding protein 70

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8262120..8264451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079550.4 → NP_524274.1  replication protein A1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524274.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24492, Q9VHU3
      Related
      FBpp0081356
      Conserved Domains (5) summary
      cd04474
      Location:168 → 270
      RPA1_DBD_A; RPA1_DBD_A: A subfamily of OB folds corresponding to the second OB fold, the ssDNA-binding domain (DBD)-A, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
      cd04475
      Location:301 → 401
      RPA1_DBD_B; RPA1_DBD_B: A subfamily of OB folds corresponding to the third OB fold, the ssDNA-binding domain (DBD)-B, of human RPA1 (also called RPA70). RPA1 is the large subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which ...
      TIGR00617
      Location:3 → 595
      rpa1; replication factor-a protein 1 (rpa1)
      pfam04057
      Location:6 → 107
      Rep-A_N; Replication factor-A protein 1, N-terminal domain
      pfam08646
      Location:444 → 589
      Rep_fac-A_C; Replication factor-A C terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q24492.1 Q24492

    Gene LinkOut

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