Pmvk Phosphomevalonate kinase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pmvkprovided by FlyBase
Official Full Name: Phosphomevalonate kinaseprovided by FlyBase
Primary source: FLYBASE:FBgn0032811
Locus tag: Dmel_CG10268
See related: AllianceGenome:FB:FBgn0032811
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:SD12705; CG10268; Dmel\CG10268; MevPK; PMVK
Summary: Predicted to enable phosphomevalonate kinase activity. Predicted to be involved in cholesterol biosynthetic process and isopentenyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in peroxisome. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human PMVK (phosphomevalonate kinase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (19579093..19580351, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (19579093..19580351, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables phosphomevalonate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphomevalonate kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphomevalonate kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in cholesterol biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in isoprenoid biosynthetic process	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed

NP_609992.1

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The following sections contain reference sequences that belong to a specific genome build. Explain